Tnkase and Acute kidney failure - a phase IV clinical study of FDA data

Summary:

Acute kidney failure is reported as a side effect among people who take Tnkase (tenecteplase), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Heparin, and have Heart attack.

The phase IV clinical study analyzes which people have Acute kidney failure when taking Tnkase. It is created by eHealthMe based on reports of 773 people who have side effects when taking Tnkase from the FDA, and is updated regularly.

What is Tnkase?

Tnkase has active ingredients of tenecteplase. eHealthMe is studying from 774 Tnkase users. Check the latest studies of Tnkase.

What is Acute kidney failure?

Acute kidney failure is found to be associated with 2,836 drugs and 4,493 conditions by eHealthMe. Check the latest studies of Acute kidney failure.

On Jul, 28, 2026

773 people reported to have side effects when taking Tnkase.
Among them, 15 people (1.94%) have Acute kidney failure.

Could Tnkase cause Acute kidney failure?

Among these 15 people:

How long have people been on Tnkase when they have Acute kidney failure? *

What is the gender of people who have Acute kidney failure when taking Tnkase? *

female: 23.08 %
male: 76.92 %

What is the age of people who have Acute kidney failure when taking Tnkase? *

What are other drugs people take besides Tnkase? *

What are other side effects people have besides Acute kidney failure? *

Cardiogenic Shock (inadequate circulation of blood): 6 people, 40.00%
Cytolytic Hepatitis (dissolution or destruction of a liver cell): 5 people, 33.33%
Pneumonia: 5 people, 33.33%
Multi-Organ Failure (multisystem organ failure): 5 people, 33.33%
Fatigue (feeling of tiredness): 3 people, 20.00%
Gastric Haemorrhage (bleeding stomach): 3 people, 20.00%
Gastric Erosions (gradual destruction of surface layer of the membrane lining the stomach): 2 people, 13.33%
Ventricular Fibrillation (abnormally irregular heart rhythm): 2 people, 13.33%
Haemoglobin Decreased: 2 people, 13.33%
Haematemesis (vomiting of blood): 2 people, 13.33%

What are the existing conditions these people have? *

Heart Attack: 5 people, 33.33%
Thrombolysis (resolving the blood clot): 2 people, 13.33%
Shock (a life-threatening condition with symptoms like low blood pressure, weakness, shallow breathing, cold, clammy skin): 2 people, 13.33%
Radiculopathy (a set of conditions in which one or more nerves is affected and does not work properly): 2 people, 13.33%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 2 people, 13.33%
Local Anaesthesia: 2 people, 13.33%
Ischaemic Stroke (stroke; caused by an interruption in the flow of blood to the brain): 2 people, 13.33%
Insomnia (sleeplessness): 2 people, 13.33%
Hyperkalemia (damage to or disease of the kidney): 2 people, 13.33%
High Blood Pressure: 2 people, 13.33%

* Approximation only. Some reports may have incomplete information.

Do you take Tnkase and have Acute kidney failure?

- Check whether Acute kidney failure is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tnkase:

Tnkase (774 reports)

Browse all side effects of Tnkase:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Acute kidney failure:

Acute kidney failure (2,836 drugs)

Browse all the conditions that are associated with Acute kidney failure:

Acute kidney failure (4,493 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tenecteplase (the active ingredients of Tnkase) and Tnkase (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.