Tolterodine and Mental status changes - a phase IV clinical study of FDA data

Summary:

Mental status changes is reported as a side effect among people who take Tolterodine (tolterodine tartrate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Acyclovir, and have Muscle spasticity.

The phase IV clinical study analyzes which people have Mental status changes when taking Tolterodine. It is created by eHealthMe based on reports of 8,075 people who have side effects when taking Tolterodine from the FDA, and is updated regularly.

What is Tolterodine?

Tolterodine has active ingredients of tolterodine tartrate. It is often used in urge incontinence. eHealthMe is studying from 8,156 Tolterodine users. Check the latest studies of Tolterodine.

What is Mental status changes?

Mental status changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation) is found to be associated with 1,491 drugs and 1,760 conditions by eHealthMe. Check the latest studies of Mental status changes.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

8,075 people reported to have side effects when taking Tolterodine.
Among them, 24 people (0.3%) have Mental status changes.

Could Tolterodine cause Mental status changes?

Among these 24 people:

How long have people been on Tolterodine when they have Mental status changes? *

What is the gender of people who have Mental status changes when taking Tolterodine? *

female: 65.22 %
male: 34.78 %

What is the age of people who have Mental status changes when taking Tolterodine? *

What are other drugs people take besides Tolterodine? *

What are other side effects people have besides Mental status changes? *

Confusional State: 7 people, 29.17%
Fatigue (feeling of tiredness): 6 people, 25.00%
Nausea (feeling of having an urge to vomit): 6 people, 25.00%
Weakness: 5 people, 20.83%
Hypokalemia (low potassium): 4 people, 16.67%
Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 4 people, 16.67%
Urinary Tract Infection: 4 people, 16.67%
Pleural Effusion (water on the lungs): 4 people, 16.67%
Oedema (fluid collection in tissue): 3 people, 12.50%
Pneumonia: 3 people, 12.50%

What are the existing conditions these people have? *

Neurogenic Bladder (the normal function of the bladder is to store and empty urine in a coordinated, controlled fashion): 3 people, 12.50%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 12.50%
Pain: 2 people, 8.33%
High Blood Pressure: 2 people, 8.33%
Laryngitis Bacterial (inflammation of the larynx caused by a bacterial infection): 2 people, 8.33%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 2 people, 8.33%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 1 person, 4.17%
Constipation: 1 person, 4.17%
Breakthrough Pain: 1 person, 4.17%
Belching (release of gas from the digestive tract): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Tolterodine and have Mental status changes?

- Check whether Mental status changes is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tolterodine:

Tolterodine (8,156 reports)

Browse all side effects of Tolterodine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Mental status changes:

Mental status changes (1,491 drugs)

Browse all the conditions that are associated with Mental status changes:

Mental status changes (1,760 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tolterodine tartrate (the active ingredients of Tolterodine) and Tolterodine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.