Topamax and Metaplasia - a phase IV clinical study of FDA data

Summary:

Metaplasia is reported as a side effect among people who take Topamax (topiramate), especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years also take Cytoxan, and have Metastases to bone.

The phase IV clinical study analyzes which people have Metaplasia when taking Topamax. It is created by eHealthMe based on reports of 54,158 people who have side effects when taking Topamax from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,954 Topamax users. Check the latest studies of Topamax.

What is Metaplasia?

Metaplasia (change in the type of adult cells in a tissue to a form abnormal for that tissue) is found to be associated with 218 drugs and 250 conditions by eHealthMe. Check the latest studies of Metaplasia.

On Jul, 17, 2026

54,158 people reported to have side effects when taking Topamax.
Among them, 14 people (0.03%) have Metaplasia.

Among these 14 people:

How long have people been on Topamax when they have Metaplasia? *

What is the gender of people who have Metaplasia when taking Topamax? *

female: 64.29 %
male: 35.71 %

What is the age of people who have Metaplasia when taking Topamax? *

What are other drugs people take besides Topamax? *

What are other side effects people have besides Metaplasia? *

Pain In Extremity: 11 people, 78.57%
Pain: 10 people, 71.43%
Dizziness: 9 people, 64.29%
Spinal Osteoarthritis (joint cartilage loss in spine): 8 people, 57.14%
Stress And Anxiety: 8 people, 57.14%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 8 people, 57.14%
Cervical Spinal Stenosis (narrowing of the spinal canal in the neck): 8 people, 57.14%
Musculoskeletal Pain (pain affects the bones, muscles, ligaments, tendons, and nerves): 8 people, 57.14%
Hypoaesthesia (reduced sense of touch or sensation): 8 people, 57.14%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 8 people, 57.14%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 7 people, 50.00%
Renal Osteodystrophy (a bone disease occurs when the kidneys fail to maintain the proper levels of calcium and phosphorus in the blood): 2 people, 14.29%
Joint Pain: 2 people, 14.29%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 2 people, 14.29%
Headache (pain in head): 2 people, 14.29%
Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 2 people, 14.29%
Catheter Related Complication: 2 people, 14.29%
Weight Loss: 1 person, 7.14%
Oesophagitis (inflammation of oesophagus): 1 person, 7.14%
Impaired Gastric Emptying: 1 person, 7.14%

* Approximation only. Some reports may have incomplete information.

Do you take Topamax and have Metaplasia?

- Check whether Metaplasia is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topamax:

Topamax (58,954 reports)

Metaplasia treatments and more:

Metaplasia (752 reports)

Browse all side effects of Topamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metaplasia:

Metaplasia (218 drugs)

Browse all the conditions that are associated with Metaplasia:

Metaplasia (250 conditions)

Related publications that referenced our studies

Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topamax) and Topamax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.