Topamax and Toxic encephalopathy - a phase IV clinical study of FDA data

Summary:

Toxic encephalopathy is reported as a side effect among people who take Topamax (topiramate), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Buspar, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Toxic encephalopathy when taking Topamax. It is created by eHealthMe based on reports of 54,158 people who have side effects when taking Topamax from the FDA, and is updated regularly.

What is Topamax?

Topamax has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 58,956 Topamax users. Check the latest studies of Topamax.

What is Toxic encephalopathy?

Toxic encephalopathy (a degenerative neurologic disorder caused by exposure to toxic substances) is found to be associated with 422 drugs and 617 conditions by eHealthMe. Check the latest studies of Toxic encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

54,158 people reported to have side effects when taking Topamax.
Among them, 13 people (0.02%) have Toxic encephalopathy.

Could Topamax cause Toxic encephalopathy?

Among these 13 people:

How long have people been on Topamax when they have Toxic encephalopathy? *

What is the gender of people who have Toxic encephalopathy when taking Topamax? *

female: 53.85 %
male: 46.15 %

What is the age of people who have Toxic encephalopathy when taking Topamax? *

What are other drugs people take besides Topamax? *

What are other side effects people have besides Toxic encephalopathy? *

Abdominal Distension: 5 people, 38.46%
Fatigue (feeling of tiredness): 5 people, 38.46%
Chest Pain: 5 people, 38.46%
Arrhythmias (irregular heartbeat): 5 people, 38.46%
Drowsiness: 5 people, 38.46%
Hepatic Failure (liver failure): 4 people, 30.77%
Electrolyte Imbalance: 4 people, 30.77%
Glycosylated Haemoglobin Increased: 4 people, 30.77%
Heart Attack: 4 people, 30.77%
Hypoglycemia (low blood sugar): 4 people, 30.77%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 30.77%
Weight Decreased: 1 person, 7.69%
Stress And Anxiety: 1 person, 7.69%
Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 1 person, 7.69%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 1 person, 7.69%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 1 person, 7.69%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 1 person, 7.69%
High Blood Pressure: 1 person, 7.69%
High Blood Cholesterol: 1 person, 7.69%
Bipolar Disorder (mood disorder): 1 person, 7.69%

* Approximation only. Some reports may have incomplete information.

Do you take Topamax and have Toxic encephalopathy?

- Check whether Toxic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topamax:

Topamax (58,956 reports)

Browse all side effects of Topamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toxic encephalopathy:

Toxic encephalopathy (422 drugs)

Browse all the conditions that are associated with Toxic encephalopathy:

Toxic encephalopathy (617 conditions)

Related publications that referenced our studies

Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .
Jeong SY, Jeon SJ, Kim YR, Choi SS, Kwak HS, "A Rare Case of Viagra Induced Toxic Encephalopathy", Investigative Magnetic Resonance Imaging, 2016 Sep .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topamax) and Topamax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.