Topiramate and Folate deficiency - a phase IV clinical study of FDA data

Summary:

Folate deficiency is reported as a side effect among people who take Topiramate (topiramate), especially for people who are female, 30-39 old, also take Escitalopram, and have Intentional self-injury.

The phase IV clinical study analyzes which people have Folate deficiency when taking Topiramate. It is created by eHealthMe based on reports of 48,099 people who have side effects when taking Topiramate from the FDA, and is updated regularly.

What is Topiramate?

Topiramate has active ingredients of topiramate. It is often used in migraine. eHealthMe is studying from 49,809 Topiramate users. Check the latest studies of Topiramate.

What is Folate deficiency?

Folate deficiency (lack of folic acid) is found to be associated with 227 drugs and 403 conditions by eHealthMe. Check the latest studies of Folate deficiency.

On Jul, 14, 2026

48,099 people reported to have side effects when taking Topiramate.
Among them, 20 people (0.04%) have Folate deficiency.

Could Topiramate cause Folate deficiency?

Among these 20 people:

What is the gender of people who have Folate deficiency when taking Topiramate? *

female: 88.89 %
male: 11.11 %

What is the age of people who have Folate deficiency when taking Topiramate? *

What are other drugs people take besides Topiramate? *

What are other side effects people have besides Folate deficiency? *

Tongue Ulceration (ulcers on tongue): 13 people, 65.00%
Glossodynia (a burning or painful sensation in the tongue): 12 people, 60.00%
Anaemia (lack of blood): 3 people, 15.00%
White Blood Cell Count Decreased: 2 people, 10.00%
Malaise (a feeling of general discomfort or uneasiness): 2 people, 10.00%
Adverse Event: 2 people, 10.00%
Cardiac Failure: 2 people, 10.00%
Celiac Disease - Sprue (a disease of the small intestine): 2 people, 10.00%
Cough: 2 people, 10.00%
Dyspnea (difficult or laboured breathing): 2 people, 10.00%

What are the existing conditions these people have? *

Neuralgia (pain in one or more nerves): 13 people, 65.00%
Intentional Self-Injury: 13 people, 65.00%
Thrombosis (formation of a blood clot inside a blood vessel): 10 people, 50.00%
Stress And Anxiety: 10 people, 50.00%
Pain: 10 people, 50.00%
Obsessive-Compulsive Disorder (an anxiety disorder characterized by intrusive thoughts that produce uneasiness, apprehension, fear, or worry;): 10 people, 50.00%
Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 10.00%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Topiramate and have Folate deficiency?

- Check whether Folate deficiency is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topiramate:

Topiramate (49,809 reports)

Browse all side effects of Topiramate:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Folate deficiency:

Folate deficiency (227 drugs)

Browse all the conditions that are associated with Folate deficiency:

Folate deficiency (403 conditions)

Related publications that referenced our studies

Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .
Baloch M, Siddiqui MA, "Topiramate induced sudden loss of vision", JPMA, 2012 Oct .
Kocamaz, M., & Karadag, O., "Topiramate-Induced Acute Myopia, Diplopia, and Photosensitivity: A Case Report", Beyoglu Eye Journal, 2019 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on topiramate (the active ingredients of Topiramate) and Topiramate (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.