Topotecan and Hepatic function abnormal - a phase IV clinical study of FDA data

Summary:

Hepatic function abnormal is reported as a side effect among people who take Topotecan (topotecan hydrochloride), especially for people who are male, 50-59 old, have been taking the drug for < 1 month also take Cisplatin, and have Pancreatic neuroendocrine tumor.

The phase IV clinical study analyzes which people have Hepatic function abnormal when taking Topotecan. It is created by eHealthMe based on reports of 5,841 people who have side effects when taking Topotecan from the FDA, and is updated regularly.

What is Topotecan?

Topotecan has active ingredients of topotecan hydrochloride. eHealthMe is studying from 5,853 Topotecan users. Check the latest studies of Topotecan.

What is Hepatic function abnormal?

Hepatic function abnormal is found to be associated with 1,438 drugs and 2,021 conditions by eHealthMe. Check the latest studies of Hepatic function abnormal.

On Jul, 15, 2026

5,841 people reported to have side effects when taking Topotecan.
Among them, 16 people (0.27%) have Hepatic function abnormal.

Could Topotecan cause Hepatic function abnormal?

Among these 16 people:

How long have people been on Topotecan when they have Hepatic function abnormal? *

What is the gender of people who have Hepatic function abnormal when taking Topotecan? *

female: 40 %
male: 60 %

What is the age of people who have Hepatic function abnormal when taking Topotecan? *

What are other drugs people take besides Topotecan? *

Cisplatin: 8 people, 50.00%
Lansoprazole: 6 people, 37.50%
Irinotecan Hydrochloride: 4 people, 25.00%
Afinitor: 4 people, 25.00%
Aldactone: 4 people, 25.00%
Sandostatin Lar: 4 people, 25.00%
Lasix: 4 people, 25.00%
Cyclophosphamide: 3 people, 18.75%
Lyrica: 2 people, 12.50%
Allopurinol: 2 people, 12.50%

What are other side effects people have besides Hepatic function abnormal? *

Agranulocytosis (a deficiency of granulocytes in the blood, causing increased vulnerability to infection): 5 people, 31.25%
Arrhythmias (irregular heartbeat): 4 people, 25.00%
Alanine Aminotransferase Increased: 4 people, 25.00%
Cholangitis (infection of the bile duct): 4 people, 25.00%
Aspartate Aminotransferase Increased: 4 people, 25.00%
Neoplasm Malignant (cancer tumour): 4 people, 25.00%
Neoplasm Progression (growth of tumour): 4 people, 25.00%
Jaundice Cholestatic: 4 people, 25.00%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 4 people, 25.00%
Sepsis (a severe blood infection that can lead to organ failure and death): 4 people, 25.00%

What are the existing conditions these people have? *

Pancreatic Neuroendocrine Tumor: 4 people, 25.00%
Pain: 2 people, 12.50%
Metastases To Bone (cancer spreads to bone): 2 people, 12.50%
B Precursor Type Acute Leukaemia (lymphoid cancer): 2 people, 12.50%
Rhabdomyosarcoma (cancer of the bone, soft tissues, or connective tissue (e.g., tendon or cartilage)): 1 person, 6.25%
Neuroblastoma Recurrent (reoccurrence of a cancer that forms in your nerve tissue): 1 person, 6.25%
Glioblastoma Multiforme (most common and deadliest of malignant primary brain tumours in adults): 1 person, 6.25%
Bone Pain: 1 person, 6.25%
Acute Lymphocytic Leukemia (All) (cancer of the white blood cells characterized by excess lymphoblasts): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Topotecan and have Hepatic function abnormal?

- Check whether Hepatic function abnormal is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Topotecan:

Topotecan (5,853 reports)

Browse all side effects of Topotecan:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic function abnormal:

Hepatic function abnormal (1,438 drugs)

Browse all the conditions that are associated with Hepatic function abnormal:

Hepatic function abnormal (2,021 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on topotecan hydrochloride (the active ingredients of Topotecan) and Topotecan (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.