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Tradjenta and Osteoporosis - a phase IV clinical study of FDA data

Summary:

Osteoporosis is reported as a side effect among people who take Tradjenta (linagliptin), especially for people who are male, 50-59 old, also take Truvada, and have Hiv infection.

The phase IV clinical study analyzes which people have Osteoporosis when taking Tradjenta. It is created by eHealthMe based on reports of 9,889 people who have side effects when taking Tradjenta from the FDA, and is updated regularly.

What is Tradjenta?

Tradjenta has active ingredients of linagliptin. It is often used in diabetes. eHealthMe is studying from 9,987 Tradjenta users. Check the latest studies of Tradjenta.

What is Osteoporosis?

Osteoporosis (bones weak and more likely to break) is found to be associated with 1,806 drugs and 1,905 conditions by eHealthMe. Check the latest studies of Osteoporosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

9,889 people reported to have side effects when taking Tradjenta.
Among them, 24 people (0.24%) have Osteoporosis.

Could Tradjenta cause Osteoporosis?

Among these 24 people:

What is the gender of people who have Osteoporosis when taking Tradjenta? *

  • female: 45.83 %
  • male: 54.17 %

What is the age of people who have Osteoporosis when taking Tradjenta? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 11.11 %
  • 40-49: 0.0 %
  • 50-59: 77.78 %
  • 60+: 11.11 %

What are other drugs people take besides Tradjenta? *

  1. Truvada: 11 people, 45.83%
  2. Metformin: 9 people, 37.50%
  3. Descovy: 8 people, 33.33%
  4. Lyrica: 8 people, 33.33%
  5. Isentress: 8 people, 33.33%
  6. Zetia: 7 people, 29.17%
  7. Tamsulosin: 7 people, 29.17%
  8. Atripla: 7 people, 29.17%
  9. Tresiba: 6 people, 25.00%
  10. Oxycodone: 6 people, 25.00%

What are other side effects people have besides Osteoporosis? *

  1. Pain: 16 people, 66.67%
  2. Emotional Distress: 15 people, 62.50%
  3. Anhedonia (inability to experience pleasure from activities usually found enjoyable): 15 people, 62.50%
  4. Stress And Anxiety: 15 people, 62.50%
  5. Bone Density Decreased: 12 people, 50.00%
  6. Gait Disturbance: 9 people, 37.50%
  7. Osteopenia (a condition where bone mineral density is lower than normal): 7 people, 29.17%
  8. Multiple Fractures: 7 people, 29.17%
  9. Bone Loss: 6 people, 25.00%
  10. Chronic Kidney Disease: 6 people, 25.00%

What are the existing conditions these people have? *

  1. Hiv Infection: 15 people, 62.50%
  2. Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 4 people, 16.67%
  3. High Blood Pressure: 3 people, 12.50%
  4. High Blood Cholesterol: 2 people, 8.33%
  5. Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 4.17%
  6. Bladder Spasm: 1 person, 4.17%
  7. Blood Testosterone Decreased: 1 person, 4.17%
  8. Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 1 person, 4.17%
  9. Diabetic Eye Disease: 1 person, 4.17%
  10. Drug Eruption (adverse drug reaction of the skin): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Tradjenta and have Osteoporosis?

- Check whether Osteoporosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tradjenta:

Osteoporosis treatments and more:

How severe was Osteoporosis and when was it recovered:

Expand to all the drugs that have ingredients of linagliptin:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tradjenta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Osteoporosis:

Browse all the conditions that are associated with Osteoporosis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on linagliptin (the active ingredients of Tradjenta) and Tradjenta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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