Trihexyphenidyl hydrochloride and Weakness - a phase IV clinical study of FDA data

Summary:

Weakness is reported as a side effect among people who take Trihexyphenidyl hydrochloride (trihexyphenidyl hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Palbociclib, and have Schizophrenia.

The phase IV clinical study analyzes which people have Weakness when taking Trihexyphenidyl hydrochloride. It is created by eHealthMe based on reports of 1,053 people who have side effects when taking Trihexyphenidyl hydrochloride from the FDA, and is updated regularly.

What is Trihexyphenidyl hydrochloride?

Trihexyphenidyl hydrochloride has active ingredients of trihexyphenidyl hydrochloride. It is often used in parkinson's disease. eHealthMe is studying from 1,118 Trihexyphenidyl hydrochloride users. Check the latest studies of Trihexyphenidyl hydrochloride.

What is Weakness?

Weakness is found to be associated with 3,640 drugs and 6,613 conditions by eHealthMe. Check the latest studies of Weakness.

On Jul, 09, 2026

1,053 people reported to have side effects when taking Trihexyphenidyl hydrochloride.
Among them, 18 people (1.71%) have Weakness.

Could Trihexyphenidyl hydrochloride cause Weakness?

Among these 18 people:

How long have people been on Trihexyphenidyl hydrochloride when they have Weakness? *

What is the gender of people who have Weakness when taking Trihexyphenidyl hydrochloride? *

female: 44.44 %
male: 55.56 %

What is the age of people who have Weakness when taking Trihexyphenidyl hydrochloride? *

What are other drugs people take besides Trihexyphenidyl hydrochloride? *

What are other side effects people have besides Weakness? *

Fall: 5 people, 27.78%
Confusional State: 4 people, 22.22%
Fatigue (feeling of tiredness): 3 people, 16.67%
Dizziness: 3 people, 16.67%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 3 people, 16.67%
Aggression: 3 people, 16.67%
Confusion: 2 people, 11.11%
Eosinophil Count Increased: 2 people, 11.11%
Mental Disorder (a psychological term for a mental or behavioural pattern or anomaly that causes distress or disability): 2 people, 11.11%
Mean Platelet Volume Decreased (less than normal average size of platelet cells in blood): 2 people, 11.11%

What are the existing conditions these people have? *

Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 16.67%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 11.11%
Sleep Disorder: 2 people, 11.11%
Breast Cancer Metastatic: 2 people, 11.11%
Delusion (a false belief or opinion): 2 people, 11.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.56%
Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 1 person, 5.56%
Blood Pressure Abnormal: 1 person, 5.56%
Cardiomyopathy (weakening of the heart muscle): 1 person, 5.56%
Constipation: 1 person, 5.56%

* Approximation only. Some reports may have incomplete information.

Do you take Trihexyphenidyl hydrochloride and have Weakness?

- Check whether Weakness is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trihexyphenidyl hydrochloride:

Trihexyphenidyl hydrochloride (1,118 reports)

Weakness treatments and more:

Weakness (586,876 reports)

Browse all side effects of Trihexyphenidyl hydrochloride:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weakness:

Weakness (3,640 drugs)

Browse all the conditions that are associated with Weakness:

Weakness (6,613 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on trihexyphenidyl hydrochloride (the active ingredients of Trihexyphenidyl hydrochloride) and Trihexyphenidyl hydrochloride (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.