Trulicity and Sleeping difficulty - a phase IV clinical study of FDA data

Summary:

Sleeping difficulty is reported as a side effect among people who take Trulicity (dulaglutide), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Metformin, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Sleeping difficulty when taking Trulicity. It is created by eHealthMe based on reports of 76,923 people who have side effects when taking Trulicity from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,527 Trulicity users. Check the latest studies of Trulicity.

What is Sleeping difficulty?

Sleeping difficulty (difficult sleeping) is found to be associated with 4,227 drugs and 5,350 conditions by eHealthMe. Check the latest studies of Sleeping difficulty.

On Nov, 16, 2025

76,923 people reported to have side effects when taking Trulicity.
Among them, 426 people (0.55%) have Sleeping difficulty.

Could Trulicity cause Sleeping difficulty?

Among these 426 people:

How long have people been on Trulicity when they have Sleeping difficulty? *

What is the gender of people who have Sleeping difficulty when taking Trulicity? *

female: 62.86 %
male: 37.14 %

What is the age of people who have Sleeping difficulty when taking Trulicity? *

What are other drugs people take besides Trulicity? *

What are other side effects people have besides Sleeping difficulty? *

Nausea (feeling of having an urge to vomit): 106 people, 24.88%
Fatigue (feeling of tiredness): 80 people, 18.78%
Diarrhea: 66 people, 15.49%
Dizziness: 62 people, 14.55%
Nausea And Vomiting: 58 people, 13.62%
Blood Glucose Increased: 55 people, 12.91%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 54 people, 12.68%
Weakness: 52 people, 12.21%
Stress And Anxiety: 51 people, 11.97%
Headache (pain in head): 48 people, 11.27%

What are the existing conditions these people have? *

Type 2 Diabetes: 125 people, 29.34%
Diabetes: 76 people, 17.84%
Pain: 15 people, 3.52%
Cushing's Syndrome (obesity, a rounded face, increased fat): 14 people, 3.29%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 12 people, 2.82%
Cardiac Failure: 10 people, 2.35%
Fibromyalgia (a long-term condition which causes pain all over the body): 10 people, 2.35%
Nausea (feeling of having an urge to vomit): 10 people, 2.35%
High Blood Pressure: 10 people, 2.35%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 9 people, 2.11%

* Approximation only. Some reports may have incomplete information.

Do you take Trulicity and have Sleeping difficulty?

- Check whether Sleeping difficulty is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trulicity:

Trulicity (77,527 reports)

Common Trulicity side effects:

Browse all side effects of Trulicity:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sleeping difficulty:

Browse all the drugs that are associated with Sleeping difficulty:

Sleeping difficulty (4,227 drugs)

Common conditions associated with Sleeping difficulty:

Depression: 17,540 reports
Antidepressant therapy: 17,500 reports
Pain exacerbated: 13,668 reports
Rheumatoid arthritis aggravated: 13,625 reports
Alternative medicine - pain relief: 13,485 reports
Ms: 12,998 reports
Hypertension aggravated: 12,107 reports
High blood pressure: 12,061 reports
Anxiety: 10,449 reports
Tension: 10,431 reports

Browse all the conditions that are associated with Sleeping difficulty:

Sleeping difficulty (5,350 conditions)

Drugs similar to Trulicity and Sleeping difficulty :

How the study uses the data?

The study uses data from the FDA. It is based on dulaglutide (the active ingredients of Trulicity) and Trulicity (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.