Trulicity and Weight fluctuation - a phase IV clinical study of FDA data

Summary:

Weight fluctuation is reported as a side effect among people who take Trulicity (dulaglutide), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Metformin, and have Type 2 diabetes.

The phase IV clinical study analyzes which people have Weight fluctuation when taking Trulicity. It is created by eHealthMe based on reports of 76,923 people who have side effects when taking Trulicity from the FDA, and is updated regularly.

What is Trulicity?

Trulicity has active ingredients of dulaglutide. It is often used in weight loss. eHealthMe is studying from 77,529 Trulicity users. Check the latest studies of Trulicity.

What is Weight fluctuation?

Weight fluctuation is found to be associated with 898 drugs and 1,030 conditions by eHealthMe. Check the latest studies of Weight fluctuation.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

76,923 people reported to have side effects when taking Trulicity.
Among them, 53 people (0.07%) have Weight fluctuation.

Could Trulicity cause Weight fluctuation?

Among these 53 people:

How long have people been on Trulicity when they have Weight fluctuation? *

What is the gender of people who have Weight fluctuation when taking Trulicity? *

female: 55.1 %
male: 44.9 %

What is the age of people who have Weight fluctuation when taking Trulicity? *

What are other drugs people take besides Trulicity? *

What are other side effects people have besides Weight fluctuation? *

Nausea (feeling of having an urge to vomit): 17 people, 32.08%
Headache (pain in head): 16 people, 30.19%
Fatigue (feeling of tiredness): 15 people, 28.30%
Abdominal Discomfort: 13 people, 24.53%
Weakness: 11 people, 20.75%
Pain: 11 people, 20.75%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 10 people, 18.87%
Stress And Anxiety: 9 people, 16.98%
Blood Glucose Increased: 9 people, 16.98%
Drowsiness: 9 people, 16.98%

What are the existing conditions these people have? *

Type 2 Diabetes: 14 people, 26.42%
Neuropathy Peripheral (surface nerve damage): 7 people, 13.21%
Diabetes: 7 people, 13.21%
Cardiac Failure: 4 people, 7.55%
Stress And Anxiety: 4 people, 7.55%
Immunodeficiency Common Variable: 4 people, 7.55%
High Blood Cholesterol: 3 people, 5.66%
Hypogammaglobulinaemia (an abnormally low concentration of gamma globulin in the blood and increased risk of infection): 3 people, 5.66%
Blood Glucose Abnormal: 3 people, 5.66%
Pain: 2 people, 3.77%

* Approximation only. Some reports may have incomplete information.

Do you take Trulicity and have Weight fluctuation?

- Check whether Weight fluctuation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Trulicity:

Trulicity (77,529 reports)

Browse all side effects of Trulicity:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight fluctuation:

Weight fluctuation (898 drugs)

Browse all the conditions that are associated with Weight fluctuation:

Weight fluctuation (1,030 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on dulaglutide (the active ingredients of Trulicity) and Trulicity (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.