Twynsta and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Twynsta (amlodipine besylate; telmisartan), especially for people who are female, 60+ old, also take Spiriva, and have Prostate cancer.

The phase IV clinical study analyzes which people have Malaise when taking Twynsta. It is created by eHealthMe based on reports of 1,017 people who have side effects when taking Twynsta from the FDA, and is updated regularly.

What is Twynsta?

Twynsta has active ingredients of amlodipine besylate; telmisartan. It is often used in high blood pressure. eHealthMe is studying from 1,063 Twynsta users. Check the latest studies of Twynsta.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,491 drugs and 5,128 conditions by eHealthMe. Check the latest studies of Malaise.

On Aug, 11, 2026

1,017 people reported to have side effects when taking Twynsta.
Among them, 24 people (2.36%) have Malaise.

Among these 24 people:

What is the gender of people who have Malaise when taking Twynsta? *

female: 57.89 %
male: 42.11 %

What is the age of people who have Malaise when taking Twynsta? *

What are other drugs people take besides Twynsta? *

What are other side effects people have besides Malaise? *

Fatigue (feeling of tiredness): 13 people, 54.17%
Fever: 11 people, 45.83%
Nasopharyngitis (inflammation of the nasopharynx): 8 people, 33.33%
Dyspnea (difficult or laboured breathing): 8 people, 33.33%
Injection Site Pain: 6 people, 25.00%
Weight Decreased: 6 people, 25.00%
Weakness: 6 people, 25.00%
Hot Flush (sudden feelings of heat): 6 people, 25.00%
Nausea (feeling of having an urge to vomit): 6 people, 25.00%
Hypotension (abnormally low blood pressure): 5 people, 20.83%

What are the existing conditions these people have? *

Headache (pain in head): 4 people, 16.67%
High Blood Cholesterol: 4 people, 16.67%
Asthma: 4 people, 16.67%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 4 people, 16.67%
Depression: 4 people, 16.67%
Prostate Cancer: 4 people, 16.67%
Ulcerative Colitis (inflammatory bowel disease (ibd). it causes swelling, ulcerations, and loss of function of the large intestine): 2 people, 8.33%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 8.33%
Osteoporosis (bones weak and more likely to break): 1 person, 4.17%
Lung Neoplasm Malignant (cancer tumour of lung): 1 person, 4.17%

* Approximation only. Some reports may have incomplete information.

Do you take Twynsta and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Twynsta:

Twynsta (1,063 reports)

Malaise treatments and more:

Malaise (529,933 reports)

How severe was Malaise and when was it recovered:

Malaise in Twynsta

Expand to all the drugs that have ingredients of amlodipine besylate; telmisartan:

Malaise and drugs with ingredients of amlodipine besylate; telmisartan

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Twynsta:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,491 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,128 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on amlodipine besylate; telmisartan (the active ingredients of Twynsta) and Twynsta (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.