Tykerb and Intervertebral disc protrusion - a phase IV clinical study of FDA data

Summary:

Intervertebral disc protrusion is reported as a side effect among people who take Tykerb (lapatinib ditosylate), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Zometa, and have High blood pressure.

The phase IV clinical study analyzes which people have Intervertebral disc protrusion when taking Tykerb. It is created by eHealthMe based on reports of 12,186 people who have side effects when taking Tykerb from the FDA, and is updated regularly.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

What is Intervertebral disc protrusion?

Intervertebral disc protrusion (spinal disc protrusion) is found to be associated with 1,532 drugs and 1,306 conditions by eHealthMe. Check the latest studies of Intervertebral disc protrusion.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

12,186 people reported to have side effects when taking Tykerb.
Among them, 31 people (0.25%) have Intervertebral disc protrusion.

Could Tykerb cause Intervertebral disc protrusion?

Among these 31 people:

How long have people been on Tykerb when they have Intervertebral disc protrusion? *

What is the gender of people who have Intervertebral disc protrusion when taking Tykerb? *

female: 93.1 %
male: 6.9 %

What is the age of people who have Intervertebral disc protrusion when taking Tykerb? *

What are other drugs people take besides Tykerb? *

What are other side effects people have besides Intervertebral disc protrusion? *

Osteonecrosis Of Jaw (death of bone of jaw): 30 people, 96.77%
Pain: 29 people, 93.55%
Stress And Anxiety: 28 people, 90.32%
Spinal Osteoarthritis (joint cartilage loss in spine): 25 people, 80.65%
Toothaches (tooth pain): 24 people, 77.42%
Hypoaesthesia (reduced sense of touch or sensation): 24 people, 77.42%
Metastases To Lung (cancer spreads to lung): 23 people, 74.19%
Fatigue (feeling of tiredness): 23 people, 74.19%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 23 people, 74.19%
Chest Pain: 23 people, 74.19%

What are the existing conditions these people have? *

High Blood Pressure: 13 people, 41.94%
Metastases To Bone (cancer spreads to bone): 12 people, 38.71%
Pain: 7 people, 22.58%
Depression: 7 people, 22.58%
Pain In Jaw: 6 people, 19.35%
Neoplasm Malignant (cancer tumour): 6 people, 19.35%
Stress And Anxiety: 2 people, 6.45%
Osteopenia (a condition where bone mineral density is lower than normal): 1 person, 3.23%
Nausea (feeling of having an urge to vomit): 1 person, 3.23%
Sleep Disorder: 1 person, 3.23%

* Approximation only. Some reports may have incomplete information.

Do you take Tykerb and have Intervertebral disc protrusion?

- Check whether Intervertebral disc protrusion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tykerb:

Tykerb (12,231 reports)

Browse all side effects of Tykerb:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,532 drugs)

Browse all the conditions that are associated with Intervertebral disc protrusion:

Intervertebral disc protrusion (1,306 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lapatinib ditosylate (the active ingredients of Tykerb) and Tykerb (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.