Tykerb and Toothaches - a phase IV clinical study of FDA data

Summary:

Toothaches is reported as a side effect among people who take Tykerb (lapatinib ditosylate), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Zometa, and have High blood pressure.

The phase IV clinical study analyzes which people have Toothaches when taking Tykerb. It is created by eHealthMe based on reports of 12,186 people who have side effects when taking Tykerb from the FDA, and is updated regularly.

What is Tykerb?

Tykerb has active ingredients of lapatinib ditosylate. It is often used in breast cancer. eHealthMe is studying from 12,231 Tykerb users. Check the latest studies of Tykerb.

What is Toothaches?

Toothaches (tooth pain) is found to be associated with 1,320 drugs and 1,606 conditions by eHealthMe. Check the latest studies of Toothaches.

On Aug, 09, 2026

12,186 people reported to have side effects when taking Tykerb.
Among them, 42 people (0.34%) have Toothaches.

Among these 42 people:

How long have people been on Tykerb when they have Toothaches? *

What is the gender of people who have Toothaches when taking Tykerb? *

female: 97.56 %
male: 2.44 %

What is the age of people who have Toothaches when taking Tykerb? *

What are other drugs people take besides Tykerb? *

What are other side effects people have besides Toothaches? *

Stress And Anxiety: 31 people, 73.81%
Pain: 31 people, 73.81%
Osteonecrosis Of Jaw (death of bone of jaw): 30 people, 71.43%
Spinal Osteoarthritis (joint cartilage loss in spine): 27 people, 64.29%
Metastases To Lung (cancer spreads to lung): 26 people, 61.90%
Metastases To Central Nervous System (cancer spreads to central nervous system): 26 people, 61.90%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 26 people, 61.90%
Fatigue (feeling of tiredness): 26 people, 61.90%
Dyspnea (difficult or laboured breathing): 24 people, 57.14%
Rashes (redness): 24 people, 57.14%

What are the existing conditions these people have? *

Metastases To Bone (cancer spreads to bone): 10 people, 23.81%
High Blood Pressure: 10 people, 23.81%
Neoplasm Malignant (cancer tumour): 8 people, 19.05%
Depression: 8 people, 19.05%
Pain In Jaw: 7 people, 16.67%
Pain: 7 people, 16.67%
Appetite Disorder (abnormal eating habits): 3 people, 7.14%
Hepatitis B: 3 people, 7.14%
Stress And Anxiety: 2 people, 4.76%
Impaired Gastric Emptying: 1 person, 2.38%

* Approximation only. Some reports may have incomplete information.

Do you take Tykerb and have Toothaches?

- Check whether Toothaches is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tykerb:

Tykerb (12,231 reports)

Toothaches treatments and more:

Toothaches (28,231 reports)

Browse all side effects of Tykerb:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Toothaches:

Toothaches (1,320 drugs)

Browse all the conditions that are associated with Toothaches:

Toothaches (1,606 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on lapatinib ditosylate (the active ingredients of Tykerb) and Tykerb (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.