Tylenol w/ codeine no. 3 and Squamous cell carcinoma - a phase IV clinical study of FDA data

Summary:

Squamous cell carcinoma is reported as a side effect among people who take Tylenol w/ codeine no. 3 (acetaminophen; codeine phosphate), especially for people who are male, 60+ old, also take Lipitor, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Squamous cell carcinoma when taking Tylenol w/ codeine no. 3. It is created by eHealthMe based on reports of 4,453 people who have side effects when taking Tylenol w/ codeine no. 3 from the FDA, and is updated regularly.

What is Tylenol w/ codeine no. 3?

Tylenol w/ codeine no. 3 has active ingredients of acetaminophen; codeine phosphate. It is often used in pain. eHealthMe is studying from 4,920 Tylenol w/ codeine no. 3 users. Check the latest studies of Tylenol w/ codeine no. 3.

What is Squamous cell carcinoma?

Squamous cell carcinoma (a cancer of a kind of epithelial cell) is found to be associated with 812 drugs and 897 conditions by eHealthMe. Check the latest studies of Squamous cell carcinoma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 31, 2026

4,453 people reported to have side effects when taking Tylenol w/ codeine no. 3.
Among them, 21 people (0.47%) have Squamous cell carcinoma.

Could Tylenol w/ codeine no. 3 cause Squamous cell carcinoma?

Among these 21 people:

What is the gender of people who have Squamous cell carcinoma when taking Tylenol w/ codeine no. 3? *

female: 23.81 %
male: 76.19 %

What is the age of people who have Squamous cell carcinoma when taking Tylenol w/ codeine no. 3? *

What are other drugs people take besides Tylenol w/ codeine no. 3? *

What are other side effects people have besides Squamous cell carcinoma? *

Lymph Follicular Hypertrophy (an increase in the size of the lymph node follicles): 12 people, 57.14%
Intervertebral Disc Protrusion (spinal disc protrusion): 12 people, 57.14%
Bone Disorder: 12 people, 57.14%
Stress And Anxiety: 12 people, 57.14%
Osteonecrosis Of Jaw (death of bone of jaw): 11 people, 52.38%
Rashes (redness): 11 people, 52.38%
Erection Problems: 10 people, 47.62%
Polyp: 8 people, 38.10%
Intervertebral Disc Degeneration (spinal disc degeneration): 8 people, 38.10%
Headache (pain in head): 8 people, 38.10%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 12 people, 57.14%
High Blood Cholesterol: 9 people, 42.86%
High Blood Pressure: 8 people, 38.10%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 7 people, 33.33%
Prostatitis (inflammation of the prostate gland): 5 people, 23.81%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 3 people, 14.29%
Tic (a sudden, repetitive, nonrhythmic motor movement or vocalization involving discrete muscle groups): 3 people, 14.29%
Joint Pain: 2 people, 9.52%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 9.52%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol w/ codeine no. 3 and have Squamous cell carcinoma?

- Check whether Squamous cell carcinoma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol w/ codeine no. 3:

Tylenol w/ codeine no. 3 (4,920 reports)

Squamous cell carcinoma treatments and more:

Squamous cell carcinoma (16,402 reports)

How severe was Squamous cell carcinoma and when was it recovered:

Squamous cell carcinoma in Tylenol w/ codeine no. 3

Expand to all the drugs that have ingredients of acetaminophen; codeine phosphate:

Squamous cell carcinoma and drugs with ingredients of acetaminophen; codeine phosphate (73 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Tylenol w/ codeine no. 3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Squamous cell carcinoma:

Squamous cell carcinoma (812 drugs)

Browse all the conditions that are associated with Squamous cell carcinoma:

Squamous cell carcinoma (897 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; codeine phosphate (the active ingredients of Tylenol w/ codeine no. 3) and Tylenol w/ codeine no. 3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.