Tylenol and Pneumatosis intestinalis - a phase IV clinical study of FDA data

Summary:

Pneumatosis intestinalis is reported as a side effect among people who take Tylenol (acetaminophen), especially for people who are female, 20-29 old, have been taking the drug for < 1 month also take Claravis, and have Acne.

The phase IV clinical study analyzes which people have Pneumatosis intestinalis when taking Tylenol. It is created by eHealthMe based on reports of 217,809 people who have side effects when taking Tylenol from the FDA, and is updated regularly.

What is Tylenol?

Tylenol has active ingredients of acetaminophen. It is often used in pain. eHealthMe is studying from 222,310 Tylenol users. Check the latest studies of Tylenol.

What is Pneumatosis intestinalis?

Pneumatosis intestinalis (air or gas in an intestine) is found to be associated with 256 drugs and 489 conditions by eHealthMe. Check the latest studies of Pneumatosis intestinalis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

217,809 people reported to have side effects when taking Tylenol.
Among them, 22 people (0.01%) have Pneumatosis intestinalis.

Could Tylenol cause Pneumatosis intestinalis?

Among these 22 people:

How long have people been on Tylenol when they have Pneumatosis intestinalis? *

What is the gender of people who have Pneumatosis intestinalis when taking Tylenol? *

female: 86.36 %
male: 13.64 %

What is the age of people who have Pneumatosis intestinalis when taking Tylenol? *

What are other drugs people take besides Tylenol? *

What are other side effects people have besides Pneumatosis intestinalis? *

Diarrhea: 12 people, 54.55%
Dermatitis (inflammation of the skin resulting from direct irritation by an external agent or an allergic reaction to it): 11 people, 50.00%
Gastroenteritis (inflammation of stomach and intestine): 11 people, 50.00%
Muscle Aches (muscle pain): 11 people, 50.00%
Lip Dry: 11 people, 50.00%
Aneurysmal Bone Cyst (benign expansile tumour-like bone lesion of uncertain etiology, composed of numerous blood filled channels): 11 people, 50.00%
Joint Pain: 11 people, 50.00%
Inflammatory Bowel Disease: 11 people, 50.00%
Colitis (inflammation of colon): 11 people, 50.00%
Small Intestinal Obstruction (blockage in small intestine): 11 people, 50.00%

What are the existing conditions these people have? *

Acne (skin problems that cause pimples): 11 people, 50.00%
Graft Versus Host Disease (the donated bone marrow or stem cells view the recipient's body as foreign, and the donated cells/bone marrow attack the body): 4 people, 18.18%
Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 3 people, 13.64%
Flatulence (flatus expelled through the anus): 2 people, 9.09%
Acute Leukaemia (blood cancer): 2 people, 9.09%
Portopulmonary Hypertension (coexistence of portal and pulmonary hypertension): 1 person, 4.55%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Tylenol and have Pneumatosis intestinalis?

- Check whether Pneumatosis intestinalis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Tylenol:

Tylenol (222,310 reports)

Browse all side effects of Tylenol:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Pneumatosis intestinalis:

Pneumatosis intestinalis (256 drugs)

Browse all the conditions that are associated with Pneumatosis intestinalis:

Pneumatosis intestinalis (489 conditions)

Related publications that referenced our studies

O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .
O'rafferty C, McElligott F, Storey L, O'marcaigh A, Smith O, "Pneumatosis intestinalis and imatinib mesylate", Annals of hematology, 2014 Oct .

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen (the active ingredients of Tylenol) and Tylenol (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.