Ultram and Hypovitaminosis - a phase IV clinical study of FDA data

Summary:

Hypovitaminosis is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 6 - 12 months also take Lyrica, and have Pain in extremity.

The phase IV clinical study analyzes which people have Hypovitaminosis when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Hypovitaminosis?

Hypovitaminosis (any of several diseases caused by deficiency of one or more vitamins) is found to be associated with 250 drugs and 374 conditions by eHealthMe. Check the latest studies of Hypovitaminosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 30, 2026

26,802 people reported to have side effects when taking Ultram.
Among them, 13 people (0.05%) have Hypovitaminosis.

Among these 13 people:

How long have people been on Ultram when they have Hypovitaminosis? *

What is the gender of people who have Hypovitaminosis when taking Ultram? *

female: 76.92 %
male: 23.08 %

What is the age of people who have Hypovitaminosis when taking Ultram? *

What are other drugs people take besides Ultram? *

What are other side effects people have besides Hypovitaminosis? *

Nausea (feeling of having an urge to vomit): 7 people, 53.85%
Vitamin B12 Deficiency: 6 people, 46.15%
Rashes (redness): 6 people, 46.15%
Tremor (trembling or shaking movements in one or more parts of your body): 6 people, 46.15%
Weakness: 5 people, 38.46%
Lymphoedema (localized fluid retention and tissue swelling): 5 people, 38.46%
Pain In Extremity: 5 people, 38.46%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 38.46%
Fall: 5 people, 38.46%
Nausea And Vomiting: 5 people, 38.46%

What are the existing conditions these people have? *

Pain In Extremity: 6 people, 46.15%
Depression: 5 people, 38.46%
Stress And Anxiety: 5 people, 38.46%
Vacterl Syndrome (syndrome seen in embryos and fetuses characterized by abnormalities of vertebrae (v), anus (a), cardiovascular tree (c), trachea (t), oesophagus (e), renal system (r), and limb buds (l), associated with the administration of sex hormones during early pregnancy): 3 people, 23.08%
Muscle Spasms (muscle contraction): 3 people, 23.08%
Diabetes: 3 people, 23.08%
Heart Palpitations (feelings or sensations that your heart is pounding or racing): 3 people, 23.08%
High Blood Pressure: 3 people, 23.08%
Lymphoedema (localized fluid retention and tissue swelling): 3 people, 23.08%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 23.08%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Hypovitaminosis?

- Check whether Hypovitaminosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Ultram (28,425 reports)

Hypovitaminosis treatments and more:

Hypovitaminosis (6,132 reports)

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypovitaminosis:

Hypovitaminosis (250 drugs)

Browse all the conditions that are associated with Hypovitaminosis:

Hypovitaminosis (374 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.