Ultram and Orthostatic hypotension - a phase IV clinical study of FDA data

Summary:

Orthostatic hypotension is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Neurontin, and have High blood pressure.

The phase IV clinical study analyzes which people have Orthostatic hypotension when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Orthostatic hypotension?

Orthostatic hypotension (a medical condition consisting of a sudden decrease in blood pressure when a person stands up) is found to be associated with 1,234 drugs and 1,336 conditions by eHealthMe. Check the latest studies of Orthostatic hypotension.

On Jul, 21, 2026

26,802 people reported to have side effects when taking Ultram.
Among them, 75 people (0.28%) have Orthostatic hypotension.

Could Ultram cause Orthostatic hypotension?

Among these 75 people:

How long have people been on Ultram when they have Orthostatic hypotension? *

What is the gender of people who have Orthostatic hypotension when taking Ultram? *

female: 42.47 %
male: 57.53 %

What is the age of people who have Orthostatic hypotension when taking Ultram? *

What are other drugs people take besides Ultram? *

What are other side effects people have besides Orthostatic hypotension? *

Fall: 31 people, 41.33%
Fatigue (feeling of tiredness): 26 people, 34.67%
Chest Pain: 26 people, 34.67%
Fainting (loss of consciousness and postural tone): 25 people, 33.33%
Dyspnea (difficult or laboured breathing): 25 people, 33.33%
Hyperlipidaemia (presence of excess lipids in the blood): 23 people, 30.67%
Nausea (feeling of having an urge to vomit): 22 people, 29.33%
Asthma: 22 people, 29.33%
Abdominal Pain Upper: 21 people, 28.00%
Oedema Peripheral (superficial swelling): 21 people, 28.00%

What are the existing conditions these people have? *

High Blood Pressure: 11 people, 14.67%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 9 people, 12.00%
Depression: 9 people, 12.00%
Insomnia (sleeplessness): 9 people, 12.00%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 9 people, 12.00%
Hypokalemia (low potassium): 8 people, 10.67%
Device Related Infection: 8 people, 10.67%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 5 people, 6.67%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 5 people, 6.67%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 4 people, 5.33%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Orthostatic hypotension?

- Check whether Orthostatic hypotension is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Ultram (28,425 reports)

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,234 drugs)

Browse all the conditions that are associated with Orthostatic hypotension:

Orthostatic hypotension (1,336 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.