Ultram and Panic attacks - a phase IV clinical study of FDA data

Summary:

Panic attacks is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are female, 40-49 old, have been taking the drug for 2 - 5 years also take Vioxx, and have High blood pressure.

The phase IV clinical study analyzes which people have Panic attacks when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Panic attacks?

Panic attacks is found to be associated with 2,606 drugs and 2,065 conditions by eHealthMe. Check the latest studies of Panic attacks.

On Oct, 12, 2025

26,802 people reported to have side effects when taking Ultram.
Among them, 208 people (0.78%) have Panic attacks.

Among these 208 people:

How long have people been on Ultram when they have Panic attacks? *

What is the gender of people who have Panic attacks when taking Ultram? *

female: 73.66 %
male: 26.34 %

What is the age of people who have Panic attacks when taking Ultram? *

What are other drugs people take besides Ultram? *

What are other side effects people have besides Panic attacks? *

Stress And Anxiety: 117 people, 56.25%
Depression: 90 people, 43.27%
High Blood Pressure: 72 people, 34.62%
Dyspnea (difficult or laboured breathing): 70 people, 33.65%
Chest Pain: 70 people, 33.65%
Headache (pain in head): 60 people, 28.85%
Fatigue (feeling of tiredness): 58 people, 27.88%
Insomnia (sleeplessness): 56 people, 26.92%
Dizziness: 55 people, 26.44%
Nausea (feeling of having an urge to vomit): 53 people, 25.48%

What are the existing conditions these people have? *

High Blood Pressure: 27 people, 12.98%
Depression: 25 people, 12.02%
Stress And Anxiety: 25 people, 12.02%
Bipolar Disorder (mood disorder): 17 people, 8.17%
Joint Pain: 13 people, 6.25%
Sleep Disorder: 11 people, 5.29%
Sciatic Nerve Injury: 11 people, 5.29%
Back Pain: 10 people, 4.81%
B-Cell Small Lymphocytic Lymphoma (blood cancer affecting b cells): 10 people, 4.81%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 10 people, 4.81%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Panic attacks?

- Check whether Panic attacks is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Ultram (28,425 reports)

Panic attacks treatments and more:

Panic attacks (65,701 reports)

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Panic attacks:

Browse all the drugs that are associated with Panic attacks:

Panic attacks (2,606 drugs)

Common conditions associated with Panic attacks:

Depression aggravated: 4,389 reports
Depression: 4,380 reports
Antidepressant therapy: 4,375 reports
Anxiety: 3,663 reports
Stress: 3,662 reports
Pain: 2,123 reports
Alternative medicine - pain relief: 2,090 reports
Ms: 1,863 reports
Panic disorder: 1,831 reports
Panic attack: 1,767 reports

Browse all the conditions that are associated with Panic attacks:

Panic attacks (2,065 conditions)

Drugs similar to Ultram and Panic attacks :

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.