Ultram and Spinal fusion surgery - a phase IV clinical study of FDA data

Summary:

Spinal fusion surgery is reported as a side effect among people who take Ultram (tramadol hydrochloride), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Xanax, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Spinal fusion surgery when taking Ultram. It is created by eHealthMe based on reports of 26,802 people who have side effects when taking Ultram from the FDA, and is updated regularly.

What is Ultram?

Ultram has active ingredients of tramadol hydrochloride. It is often used in pain. eHealthMe is studying from 28,425 Ultram users. Check the latest studies of Ultram.

What is Spinal fusion surgery?

Spinal fusion surgery is found to be associated with 493 drugs and 420 conditions by eHealthMe. Check the latest studies of Spinal fusion surgery.

On Jul, 20, 2026

26,802 people reported to have side effects when taking Ultram.
Among them, 37 people (0.14%) have Spinal fusion surgery.

Could Ultram cause Spinal fusion surgery?

Among these 37 people:

How long have people been on Ultram when they have Spinal fusion surgery? *

What is the gender of people who have Spinal fusion surgery when taking Ultram? *

female: 86.49 %
male: 13.51 %

What is the age of people who have Spinal fusion surgery when taking Ultram? *

What are other drugs people take besides Ultram? *

What are other side effects people have besides Spinal fusion surgery? *

Weakness: 19 people, 51.35%
Injury: 19 people, 51.35%
Stress And Anxiety: 19 people, 51.35%
Neck Pain: 16 people, 43.24%
Disability: 15 people, 40.54%
Bursitis (inflammation of a bursa, typically one in the knee, elbow, or shoulder): 13 people, 35.14%
Bone Pain: 13 people, 35.14%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 12 people, 32.43%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 12 people, 32.43%
Hypokalemia (low potassium): 11 people, 29.73%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 15 people, 40.54%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 8.11%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 3 people, 8.11%
Diabetes: 2 people, 5.41%
Osteoporosis (bones weak and more likely to break): 2 people, 5.41%
High Blood Pressure: 2 people, 5.41%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 2 people, 5.41%
Insomnia (sleeplessness): 2 people, 5.41%
Depression: 2 people, 5.41%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Ultram and have Spinal fusion surgery?

- Check whether Spinal fusion surgery is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Ultram:

Ultram (28,425 reports)

Browse all side effects of Ultram:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Spinal fusion surgery:

Spinal fusion surgery (493 drugs)

Browse all the conditions that are associated with Spinal fusion surgery:

Spinal fusion surgery (420 conditions)

Related publications that referenced our studies

Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .
Mansour HM, "Tramadol and Disseminated Intravascular Coagulopathy: A Case Report", Medicine Science, 2015 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on tramadol hydrochloride (the active ingredients of Ultram) and Ultram (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.