Unisom and Irritability - a phase IV clinical study of FDA data

Summary:

Irritability is reported as a side effect among people who take Unisom (doxylamine succinate), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Aleve, and have Breast cancer female.

The phase IV clinical study analyzes which people have Irritability when taking Unisom. It is created by eHealthMe based on reports of 3,362 people who have side effects when taking Unisom from the FDA, and is updated regularly.

What is Unisom?

Unisom has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 3,875 Unisom users. Check the latest studies of Unisom.

What is Irritability?

Irritability is found to be associated with 1,702 drugs and 2,458 conditions by eHealthMe. Check the latest studies of Irritability.

On Jul, 14, 2026

3,362 people reported to have side effects when taking Unisom.
Among them, 15 people (0.45%) have Irritability.

Among these 15 people:

How long have people been on Unisom when they have Irritability? *

What is the gender of people who have Irritability when taking Unisom? *

female: 61.54 %
male: 38.46 %

What is the age of people who have Irritability when taking Unisom? *

What are other drugs people take besides Unisom? *

Zometa: 2 people, 13.33%
Benadryl: 2 people, 13.33%
Ibrance: 2 people, 13.33%
Magnesium Citrate: 2 people, 13.33%
Melatonin: 2 people, 13.33%
Diphenhydramine Hydrochloride: 2 people, 13.33%
Letrozole: 2 people, 13.33%
Zantac: 2 people, 13.33%
Advil: 2 people, 13.33%
Aleve: 2 people, 13.33%

What are other side effects people have besides Irritability? *

Fatigue (feeling of tiredness): 5 people, 33.33%
Drowsiness: 4 people, 26.67%
Rhabdomyolysis (a condition in which damaged skeletal muscle tissue breaks down): 3 people, 20.00%
Headache (pain in head): 3 people, 20.00%
Stress And Anxiety: 3 people, 20.00%
Nausea And Vomiting: 2 people, 13.33%
Drug Ineffective: 2 people, 13.33%
Memory Loss: 2 people, 13.33%
Appetite - Increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires): 2 people, 13.33%
Heart Rate Increased: 2 people, 13.33%

What are the existing conditions these people have? *

Suicide Attempt: 2 people, 13.33%
Pain: 2 people, 13.33%
Breast Cancer Female: 2 people, 13.33%
Torticollis (a twisted neck in which the head is tipped to one side, while the chin is turned to the other): 1 person, 6.67%
Stress And Anxiety: 1 person, 6.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 1 person, 6.67%
Malignant Melanoma (skin cancer rises from melancytes): 1 person, 6.67%
Hallucinations (sensations that appear real but are created by your mind): 1 person, 6.67%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 6.67%
Facial Spasm (involuntary muscle contractions face): 1 person, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Unisom and have Irritability?

- Check whether Irritability is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Unisom:

Unisom (3,875 reports)

Irritability treatments and more:

Irritability (71,614 reports)

Browse all side effects of Unisom:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Irritability:

Irritability (1,702 drugs)

Browse all the conditions that are associated with Irritability:

Irritability (2,458 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on doxylamine succinate (the active ingredients of Unisom) and Unisom (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.