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Unisom and Weight increased - a phase IV clinical study of FDA data

Summary:

Weight increased is reported as a side effect among people who take Unisom (doxylamine succinate), especially for people who are female, 60+ old, also take Lyrica, and have Pain.

The phase IV clinical study analyzes which people have Weight increased when taking Unisom. It is created by eHealthMe based on reports of 3,362 people who have side effects when taking Unisom from the FDA, and is updated regularly.

What is Unisom?

Unisom has active ingredients of doxylamine succinate. It is often used in insomnia. eHealthMe is studying from 3,873 Unisom users. Check the latest studies of Unisom.

What is Weight increased?

Weight increased is found to be associated with 2,898 drugs and 3,937 conditions by eHealthMe. Check the latest studies of Weight increased.

On Apr, 12, 2026

3,362 people reported to have side effects when taking Unisom.
Among them, 33 people (0.98%) have Weight increased.

Could Unisom cause Weight increased?

Among these 33 people:

What is the gender of people who have Weight increased when taking Unisom? *

  • female: 67.74 %
  • male: 32.26 %

What is the age of people who have Weight increased when taking Unisom? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 0.0 %
  • 20-29: 0.0 %
  • 30-39: 15 %
  • 40-49: 15 %
  • 50-59: 15 %
  • 60+: 55 %

What are other drugs people take besides Unisom? *

  1. Lyrica: 15 people, 45.45%
  2. Vitamin B12: 10 people, 30.30%
  3. Vitamin D3: 8 people, 24.24%
  4. Metformin: 7 people, 21.21%
  5. Clopidogrel: 6 people, 18.18%
  6. Pantoprazole Sodium: 6 people, 18.18%
  7. Oxycodone: 6 people, 18.18%
  8. Aleve: 6 people, 18.18%
  9. Imitrex: 6 people, 18.18%
  10. Dilaudid: 6 people, 18.18%

What are other side effects people have besides Weight increased? *

  1. Memory Loss: 8 people, 24.24%
  2. Thrombosis (formation of a blood clot inside a blood vessel): 6 people, 18.18%
  3. Nervousness: 6 people, 18.18%
  4. Sinusitis (inflammation of sinus): 6 people, 18.18%
  5. Pain: 6 people, 18.18%
  6. Urinary Tract Infection: 5 people, 15.15%
  7. Depressed Mood: 5 people, 15.15%
  8. Loss Of Consciousness: 5 people, 15.15%
  9. Nerve Compression: 5 people, 15.15%
  10. Fall: 5 people, 15.15%

What are the existing conditions these people have? *

  1. Pain: 12 people, 36.36%
  2. Diabetes: 7 people, 21.21%
  3. High Blood Cholesterol: 6 people, 18.18%
  4. Neuropathy Peripheral (surface nerve damage): 6 people, 18.18%
  5. Limb Discomfort (discomfort in leg): 6 people, 18.18%
  6. Polyneuropathy Idiopathic Progressive (progressive disorder that affects the peripheral nerves and has no identifiable primary cause): 6 people, 18.18%
  7. Blood Pressure Abnormal: 6 people, 18.18%
  8. Immune System Disorder: 5 people, 15.15%
  9. Fibromyalgia (a long-term condition which causes pain all over the body): 4 people, 12.12%
  10. Hypergammaglobulinaemia (elevated levels of gamma globulin): 3 people, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Unisom and have Weight increased?

- Check whether Weight increased is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Unisom:

Weight increased treatments and more:

How severe was Weight increased and when was it recovered:

Expand to all the drugs that have ingredients of doxylamine succinate:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Unisom:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Weight increased:

Browse all the conditions that are associated with Weight increased:

How the study uses the data?

The study uses data from the FDA. It is based on doxylamine succinate (the active ingredients of Unisom) and Unisom (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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