Upneeq and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Upneeq (oxymetazoline hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Vitamins, and have Eyelid ptosis.

The phase IV clinical study analyzes which people have Headache when taking Upneeq. It is created by eHealthMe based on reports of 1,178 people who have side effects when taking Upneeq from the FDA, and is updated regularly.

What is Upneeq?

Upneeq has active ingredients of oxymetazoline hydrochloride. eHealthMe is studying from 1,180 Upneeq users. Check the latest studies of Upneeq.

What is Headache?

Headache (pain in head) is found to be associated with 3,749 drugs and 5,772 conditions by eHealthMe. Check the latest studies of Headache.

On Jul, 11, 2026

1,178 people reported to have side effects when taking Upneeq.
Among them, 108 people (9.17%) have Headache.

Among these 108 people:

* Approximation only. Some reports may have incomplete information.

Do you take Upneeq and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Upneeq:

Upneeq (1,180 reports)

Headache treatments and more:

Headache (756,642 reports)

How severe was Headache and when was it recovered:

Headache in Upneeq

Expand to all the drugs that have ingredients of oxymetazoline hydrochloride:

Headache and drugs with ingredients of oxymetazoline hydrochloride

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Upneeq:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Headache:

Headache (3,749 drugs)

Browse all the conditions that are associated with Headache:

Headache (5,772 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on oxymetazoline hydrochloride (the active ingredients of Upneeq) and Upneeq (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.