Uptravi and Rectal tenesmus - a phase IV clinical study of FDA data

Summary:

Rectal tenesmus is reported as a side effect among people who take Uptravi (selexipag), especially for people who are female, 60+ old, also take Ambrisentan, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Rectal tenesmus when taking Uptravi. It is created by eHealthMe based on reports of 26,571 people who have side effects when taking Uptravi from the FDA, and is updated regularly.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

What is Rectal tenesmus?

Rectal tenesmus (a feeling of incomplete defecation) is found to be associated with 169 drugs and 329 conditions by eHealthMe. Check the latest studies of Rectal tenesmus.

On Jul, 16, 2026

26,571 people reported to have side effects when taking Uptravi.
Among them, 12 people (0.05%) have Rectal tenesmus.

Among these 12 people:

What is the gender of people who have Rectal tenesmus when taking Uptravi? *

female: 100 %
male: 0.0 %

What is the age of people who have Rectal tenesmus when taking Uptravi? *

What are other drugs people take besides Uptravi? *

What are other side effects people have besides Rectal tenesmus? *

Nausea (feeling of having an urge to vomit): 12 people, 100.00%
Weakness: 11 people, 91.67%
Dyspnea Exertional: 11 people, 91.67%
Headache (pain in head): 11 people, 91.67%
Malaise (a feeling of general discomfort or uneasiness): 9 people, 75.00%
Diarrhea: 9 people, 75.00%
Tremor (trembling or shaking movements in one or more parts of your body): 9 people, 75.00%
Pain: 9 people, 75.00%
Feeding Disorder (when children refuse to eat certain food groups): 7 people, 58.33%
Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 7 people, 58.33%

What are the existing conditions these people have? *

Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 10 people, 83.33%
Blood Potassium Decreased: 6 people, 50.00%

* Approximation only. Some reports may have incomplete information.

Do you take Uptravi and have Rectal tenesmus?

- Check whether Rectal tenesmus is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Uptravi:

Uptravi (26,576 reports)

Rectal tenesmus treatments and more:

Rectal tenesmus (1,444 reports)

Browse all side effects of Uptravi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Rectal tenesmus:

Rectal tenesmus (169 drugs)

Browse all the conditions that are associated with Rectal tenesmus:

Rectal tenesmus (329 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on selexipag (the active ingredients of Uptravi) and Uptravi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.