Uptravi and Water retention - a phase IV clinical study of FDA data

Summary:

Water retention is reported as a side effect among people who take Uptravi (selexipag), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Opsumit, and have Primary pulmonary hypertension.

The phase IV clinical study analyzes which people have Water retention when taking Uptravi. It is created by eHealthMe based on reports of 26,571 people who have side effects when taking Uptravi from the FDA, and is updated regularly.

What is Uptravi?

Uptravi has active ingredients of selexipag. eHealthMe is studying from 26,576 Uptravi users. Check the latest studies of Uptravi.

What is Water retention?

Water retention is found to be associated with 2,100 drugs and 2,457 conditions by eHealthMe. Check the latest studies of Water retention.

On May, 12, 2026

26,571 people reported to have side effects when taking Uptravi.
Among them, 1,600 people (6.02%) have Water retention.

Among these 1,600 people:

* Approximation only. Some reports may have incomplete information.

Do you take Uptravi and have Water retention?

- Check whether Water retention is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Uptravi:

Uptravi (26,576 reports)

Water retention treatments and more:

Water retention (79,658 reports)

How severe was Water retention and when was it recovered:

Water retention in Uptravi

Expand to all the drugs that have ingredients of selexipag:

Water retention and drugs with ingredients of selexipag (1,724 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Uptravi:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Water retention:

Water retention (2,100 drugs)

Browse all the conditions that are associated with Water retention:

Water retention (2,457 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on selexipag (the active ingredients of Uptravi) and Uptravi (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.