Valacyclovir and Clostridium difficile colitis - a phase IV clinical study of FDA data

Summary:

Clostridium difficile colitis is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are male, 60+ old, have been taking the drug for < 1 month also take Bactrim, and have Nausea.

The phase IV clinical study analyzes which people have Clostridium difficile colitis when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,107 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Clostridium difficile colitis?

Clostridium difficile colitis (inflammation of colon by clostridium difficile bacteria infection) is found to be associated with 1,043 drugs and 1,781 conditions by eHealthMe. Check the latest studies of Clostridium difficile colitis.

On Jul, 05, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 91 people (0.22%) have Clostridium difficile colitis.

Could Valacyclovir cause Clostridium difficile colitis?

Among these 91 people:

How long have people been on Valacyclovir when they have Clostridium difficile colitis? *

What is the gender of people who have Clostridium difficile colitis when taking Valacyclovir? *

female: 50 %
male: 50 %

What is the age of people who have Clostridium difficile colitis when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

What are other side effects people have besides Clostridium difficile colitis? *

Mucosal Inflammation (infection of mucous membrane): 20 people, 21.98%
Pneumonia: 19 people, 20.88%
Febrile Bone Marrow Aplasia (bone marrow greatly decreases or stops production of blood cells): 16 people, 17.58%
Sepsis (a severe blood infection that can lead to organ failure and death): 11 people, 12.09%
Cytomegalovirus Viraemia (cytomegalo virus in blood stream): 8 people, 8.79%
Interstitial Lung Disease: 8 people, 8.79%
Diarrhea: 8 people, 8.79%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 8 people, 8.79%
Alpha Haemolytic Streptococcal Infection (infections with alpha-haemolytic strep bacteria are common; many strains live naturally in humans): 8 people, 8.79%
Dyspnea (difficult or laboured breathing): 7 people, 7.69%

What are the existing conditions these people have? *

Nausea (feeling of having an urge to vomit): 20 people, 21.98%
Non-Hodgkin's Lymphoma (malignant (cancer) cells form in the lymph system): 19 people, 20.88%
Multiple Myeloma (cancer of the plasma cells): 15 people, 16.48%
T-Cell Lymphoma (a blood cell cancer): 10 people, 10.99%
Acute Myeloid Leukaemia (acute cancer in which the bone marrow makes abnormal myeloblasts): 9 people, 9.89%
High Blood Pressure: 7 people, 7.69%
Pain: 7 people, 7.69%
Neuropathy Peripheral (surface nerve damage): 5 people, 5.49%
Constipation: 5 people, 5.49%
Insomnia (sleeplessness): 5 people, 5.49%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Clostridium difficile colitis?

- Check whether Clostridium difficile colitis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,107 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,043 drugs)

Browse all the conditions that are associated with Clostridium difficile colitis:

Clostridium difficile colitis (1,781 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.