Valacyclovir and Hypothyroidism - a phase IV clinical study of FDA data

Summary:

Hypothyroidism is reported as a side effect among people who take Valacyclovir (valacyclovir hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Humalog, and have Pain.

The phase IV clinical study analyzes which people have Hypothyroidism when taking Valacyclovir. It is created by eHealthMe based on reports of 41,259 people who have side effects when taking Valacyclovir from the FDA, and is updated regularly.

What is Valacyclovir?

Valacyclovir has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 42,108 Valacyclovir users. Check the latest studies of Valacyclovir.

What is Hypothyroidism?

Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development) is found to be associated with 1,617 drugs and 2,600 conditions by eHealthMe. Check the latest studies of Hypothyroidism.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 02, 2026

41,259 people reported to have side effects when taking Valacyclovir.
Among them, 57 people (0.14%) have Hypothyroidism.

Could Valacyclovir cause Hypothyroidism?

Among these 57 people:

How long have people been on Valacyclovir when they have Hypothyroidism? *

What is the gender of people who have Hypothyroidism when taking Valacyclovir? *

female: 77.78 %
male: 22.22 %

What is the age of people who have Hypothyroidism when taking Valacyclovir? *

What are other drugs people take besides Valacyclovir? *

What are other side effects people have besides Hypothyroidism? *

High Blood Pressure: 20 people, 35.09%
Fatigue (feeling of tiredness): 17 people, 29.82%
Headache (pain in head): 14 people, 24.56%
Diarrhea: 13 people, 22.81%
Pain: 11 people, 19.30%
Stress And Anxiety: 11 people, 19.30%
Fever: 9 people, 15.79%
Feeling Abnormal: 9 people, 15.79%
Malaise (a feeling of general discomfort or uneasiness): 9 people, 15.79%
Abdominal Pain: 9 people, 15.79%

What are the existing conditions these people have? *

Pain: 9 people, 15.79%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 7 people, 12.28%
Multiple Myeloma (cancer of the plasma cells): 6 people, 10.53%
Fibromyalgia (a long-term condition which causes pain all over the body): 5 people, 8.77%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 4 people, 7.02%
Muscle Spasms (muscle contraction): 4 people, 7.02%
High Blood Cholesterol: 3 people, 5.26%
Depression: 3 people, 5.26%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 3 people, 5.26%
Constipation: 3 people, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Valacyclovir and have Hypothyroidism?

- Check whether Hypothyroidism is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valacyclovir:

Valacyclovir (42,108 reports)

Hypothyroidism treatments and more:

Hypothyroidism (168,071 reports)

Browse all side effects of Valacyclovir:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hypothyroidism:

Hypothyroidism (1,617 drugs)

Browse all the conditions that are associated with Hypothyroidism:

Hypothyroidism (2,600 conditions)

Related publications that referenced our studies

Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .
Ezeji GC, Inoue T, Bahtiyar G, Sacerdote A, "Hallucinations associated with miglitol use in a patient with chronic kidney disease and hypothyroidism", BMJ case reports, 2015 Feb .

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valacyclovir) and Valacyclovir (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.