Valium and Hepatic necrosis - a phase IV clinical study of FDA data

Summary:

Hepatic necrosis is reported as a side effect among people who take Valium (diazepam), especially for people who are female, 50-59 old, have been taking the drug for 1 - 6 months also take Neurontin, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Hepatic necrosis when taking Valium. It is created by eHealthMe based on reports of 45,658 people who have side effects when taking Valium from the FDA, and is updated regularly.

What is Valium?

Valium has active ingredients of diazepam. It is often used in stress and anxiety. eHealthMe is studying from 48,647 Valium users. Check the latest studies of Valium.

What is Hepatic necrosis?

Hepatic necrosis (large portions of liver die off due to severe liver disease) is found to be associated with 588 drugs and 744 conditions by eHealthMe. Check the latest studies of Hepatic necrosis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

45,658 people reported to have side effects when taking Valium.
Among them, 20 people (0.04%) have Hepatic necrosis.

Among these 20 people:

How long have people been on Valium when they have Hepatic necrosis? *

What is the gender of people who have Hepatic necrosis when taking Valium? *

female: 60 %
male: 40 %

What is the age of people who have Hepatic necrosis when taking Valium? *

What are other drugs people take besides Valium? *

What are other side effects people have besides Hepatic necrosis? *

Sepsis (a severe blood infection that can lead to organ failure and death): 7 people, 35.00%
Encephalopathy (functioning of the brain is affected by some agent or condition): 7 people, 35.00%
Respiratory Acidosis (respiratory failure or ventilatory failure, causes the ph of blood and other bodily fluids to decrease): 6 people, 30.00%
Multi-Organ Failure (multisystem organ failure): 6 people, 30.00%
Pneumonia: 5 people, 25.00%
Appetite - Decreased (decreased appetite occurs when you have a reduced desire to eat): 4 people, 20.00%
Pain: 4 people, 20.00%
Dehydration (dryness resulting from the removal of water): 4 people, 20.00%
Autoimmune Hepatitis: 4 people, 20.00%
Consciousness - Decreased: 4 people, 20.00%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 5 people, 25.00%
Pain: 4 people, 20.00%
Nausea (feeling of having an urge to vomit): 2 people, 10.00%
Infection: 2 people, 10.00%
Hyperparathyroidism Secondary (an abnormally high concentration of parathyroid hormone in the blood, resulting in weakening of the bones through loss of calcium-secondary): 2 people, 10.00%
Urinary Tract Infection: 1 person, 5.00%
Dyslipidaemia (abnormal amount of lipids): 1 person, 5.00%
Adenocarcinoma Pancreas (cancer of pancreas): 1 person, 5.00%
Birth Control: 1 person, 5.00%
Chest Pain: 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Valium and have Hepatic necrosis?

- Check whether Hepatic necrosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valium:

Valium (48,647 reports)

Browse all side effects of Valium:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Hepatic necrosis:

Hepatic necrosis (588 drugs)

Browse all the conditions that are associated with Hepatic necrosis:

Hepatic necrosis (744 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on diazepam (the active ingredients of Valium) and Valium (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.