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Valproic acid and Apallic syndrome - a phase IV clinical study of FDA data

Summary:

Apallic syndrome is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are male, 30-39 old, have been taking the drug for < 1 month also take Promazine Hydrochloride, and have Muscle spasticity.

The phase IV clinical study analyzes which people have Apallic syndrome when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Apallic syndrome?

Apallic syndrome (serious brain damage, when cortical parts of the brain are disconnected from brainstem) is found to be associated with 115 drugs and 378 conditions by eHealthMe. Check the latest studies of Apallic syndrome.

On Jul, 07, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 12 people (0.03%) have Apallic syndrome.

Could Valproic acid cause Apallic syndrome?

Among these 12 people:

How long have people been on Valproic acid when they have Apallic syndrome? *

  • < 1 month: 66.67 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 33.33 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Apallic syndrome when taking Valproic acid? *

  • female: 45.45 %
  • male: 54.55 %

What is the age of people who have Apallic syndrome when taking Valproic acid? *

  • 0-1: 0.0 %
  • 2-9: 11.11 %
  • 10-19: 11.11 %
  • 20-29: 0.0 %
  • 30-39: 77.78 %
  • 40-49: 0.0 %
  • 50-59: 0.0 %
  • 60+: 0.0 %

What are other drugs people take besides Valproic acid? *

  1. Zyprexa: 5 people, 41.67%
  2. Clarithromycin: 5 people, 41.67%
  3. Doral: 5 people, 41.67%
  4. Tegretol: 5 people, 41.67%
  5. Haloperidol: 5 people, 41.67%
  6. Seroquel: 5 people, 41.67%
  7. Risperdal: 5 people, 41.67%
  8. Promazine Hydrochloride: 5 people, 41.67%
  9. Magnesium Sulfate: 2 people, 16.67%
  10. Alprazolam: 2 people, 16.67%

What are other side effects people have besides Apallic syndrome? *

  1. Cardio-Respiratory Arrest (sudden dysfunction of heart and lungs): 5 people, 41.67%
  2. Respiratory Depression (respiration has a rate below 12 breaths): 5 people, 41.67%
  3. Intestinal Obstruction: 5 people, 41.67%
  4. Blood Creatine Phosphokinase Increased: 4 people, 33.33%
  5. Disturbance In Attention: 3 people, 25.00%
  6. Fever: 3 people, 25.00%
  7. Subacute Sclerosing Panencephalitis (slow infection with a measles virus and characterized by progressive loss of mental and motor functions ending in dementia and paralysis): 2 people, 16.67%
  8. Ileus Paralytic (obstruction of the intestine due to paralysis of the intestinal muscles): 2 people, 16.67%
  9. Defaecation Urgency (a sudden compelling urge to defecate): 2 people, 16.67%
  10. Dizziness: 2 people, 16.67%

What are the existing conditions these people have? *

  1. Myoclonus (a brief, involuntary twitching of a muscle or a group of muscles): 3 people, 25.00%
  2. Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 3 people, 25.00%
  3. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 2 people, 16.67%
  4. Pneumonia: 2 people, 16.67%
  5. Insomnia (sleeplessness): 2 people, 16.67%
  6. Constipation: 2 people, 16.67%
  7. Tonic Convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it): 1 person, 8.33%
  8. Sepsis (a severe blood infection that can lead to organ failure and death): 1 person, 8.33%
  9. Primary Pulmonary Hypertension (primary high blood pressure that affects the arteries in the lungs and the right side of your heart): 1 person, 8.33%
  10. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Apallic syndrome?

- Check whether Apallic syndrome is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Apallic syndrome treatments and more:

How severe was Apallic syndrome and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Apallic syndrome:

Browse all the conditions that are associated with Apallic syndrome:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

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