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Valproic acid and Interstitial nephritis - a phase IV clinical study of FDA data

Summary:

Interstitial nephritis is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are female, 30-39 old, have been taking the drug for < 1 month also take Vancomycin, and have Schizoaffective disorder.

The phase IV clinical study analyzes which people have Interstitial nephritis when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Interstitial nephritis?

Interstitial nephritis (inflammation of the kidney) is found to be associated with 1,085 drugs and 1,568 conditions by eHealthMe. Check the latest studies of Interstitial nephritis.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 74 people (0.21%) have Interstitial nephritis.

Could Valproic acid cause Interstitial nephritis?

Among these 74 people:

How long have people been on Valproic acid when they have Interstitial nephritis? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Interstitial nephritis when taking Valproic acid? *

  • female: 52 %
  • male: 48 %

What is the age of people who have Interstitial nephritis when taking Valproic acid? *

  • 0-1: 0.0 %
  • 2-9: 0.0 %
  • 10-19: 8.93 %
  • 20-29: 14.29 %
  • 30-39: 39.29 %
  • 40-49: 10.71 %
  • 50-59: 16.07 %
  • 60+: 10.71 %

What are other drugs people take besides Valproic acid? *

  1. Vancomycin: 17 people, 22.97%
  2. Levetiracetam: 7 people, 9.46%
  3. Carbamazepine: 7 people, 9.46%
  4. Lamotrigine: 5 people, 6.76%
  5. Clonazepam: 4 people, 5.41%
  6. Omeprazole: 4 people, 5.41%
  7. Furosemide: 4 people, 5.41%
  8. Clozapine: 4 people, 5.41%
  9. Magnesium: 3 people, 4.05%
  10. Phenytoin: 3 people, 4.05%

What are other side effects people have besides Interstitial nephritis? *

  1. Fever: 12 people, 16.22%
  2. Acute Kidney Failure: 9 people, 12.16%
  3. Kidney Fibrosis (excess fibrous connective tissue in kidney): 8 people, 10.81%
  4. Eosinophilia (eosinophil count in the peripheral blood exceeds): 7 people, 9.46%
  5. Renal Impairment (severely reduced kidney function): 5 people, 6.76%
  6. Urine Output - Decreased: 5 people, 6.76%
  7. Rashes (redness): 5 people, 6.76%
  8. Diarrhea: 4 people, 5.41%
  9. Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 4 people, 5.41%
  10. Hepatitis (inflammation of the liver): 4 people, 5.41%

What are the existing conditions these people have? *

  1. Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 6 people, 8.11%
  2. Schizoaffective Disorder (a mental disorder characterized by disordered thought): 6 people, 8.11%
  3. Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 4 people, 5.41%
  4. Bipolar I Disorder (mood disorder that is characterized by at least one manic or mixed episode): 4 people, 5.41%
  5. Convulsion (muscles contract and relax rapidly and repeatedly, resulting in an uncontrolled shaking of the body): 4 people, 5.41%
  6. Temporal Lobe Epilepsy (a term that refers to a condition where seizures are generated in the portion of the brain called the temporal lobe): 3 people, 4.05%
  7. Infantile Spasms: 2 people, 2.70%
  8. Pain: 2 people, 2.70%
  9. Partial Seizures With Secondary Generalisation (partial seizure may spread within the brain, a process known as secondary generalization): 2 people, 2.70%
  10. High Blood Pressure: 2 people, 2.70%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Interstitial nephritis?

- Check whether Interstitial nephritis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Interstitial nephritis treatments and more:

How severe was Interstitial nephritis and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Interstitial nephritis:

Browse all the conditions that are associated with Interstitial nephritis:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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