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Valproic acid and Tonic convulsion - a phase IV clinical study of FDA data

Summary:

Tonic convulsion is reported as a side effect among people who take Valproic acid (valproic acid), especially for people who are male, 2-9 old, have been taking the drug for < 1 month also take Clobazam, and have Partial seizures.

The phase IV clinical study analyzes which people have Tonic convulsion when taking Valproic acid. It is created by eHealthMe based on reports of 35,830 people who have side effects when taking Valproic acid from the FDA, and is updated regularly.

What is Valproic acid?

Valproic acid has active ingredients of valproic acid. It is often used in epilepsy. eHealthMe is studying from 36,193 Valproic acid users. Check the latest studies of Valproic acid.

What is Tonic convulsion?

Tonic convulsion (the person will quickly lose consciousness and the skeletal muscles will suddenly tense, often causing the extremities to be pulled towards the body or rigidly pushed away from it) is found to be associated with 162 drugs and 383 conditions by eHealthMe. Check the latest studies of Tonic convulsion.

On Jul, 19, 2026

35,830 people reported to have side effects when taking Valproic acid.
Among them, 64 people (0.18%) have Tonic convulsion.

Could Valproic acid cause Tonic convulsion?

Among these 64 people:

How long have people been on Valproic acid when they have Tonic convulsion? *

  • < 1 month: 100 %
  • 1 - 6 months: 0.0 %
  • 6 - 12 months: 0.0 %
  • 1 - 2 years: 0.0 %
  • 2 - 5 years: 0.0 %
  • 5 - 10 years: 0.0 %
  • 10+ years: 0.0 %

What is the gender of people who have Tonic convulsion when taking Valproic acid? *

  • female: 35.71 %
  • male: 64.29 %

What is the age of people who have Tonic convulsion when taking Valproic acid? *

  • 0-1: 7.84 %
  • 2-9: 41.18 %
  • 10-19: 7.84 %
  • 20-29: 17.65 %
  • 30-39: 9.8 %
  • 40-49: 7.84 %
  • 50-59: 0.0 %
  • 60+: 7.84 %

What are other drugs people take besides Valproic acid? *

  1. Clobazam: 25 people, 39.06%
  2. Levetiracetam: 21 people, 32.81%
  3. Rufinamide: 14 people, 21.88%
  4. Ethosuximide: 13 people, 20.31%
  5. Topiramate: 11 people, 17.19%
  6. Carbamazepine: 9 people, 14.06%
  7. Lamotrigine: 8 people, 12.50%
  8. Clonazepam: 8 people, 12.50%
  9. Keppra: 7 people, 10.94%
  10. Vigabatrin: 7 people, 10.94%

What are other side effects people have besides Tonic convulsion? *

  1. Petit Mal Epilepsy (absence seizure): 19 people, 29.69%
  2. Multiple-Drug Resistance: 17 people, 26.56%
  3. Drug Ineffective: 13 people, 20.31%
  4. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 10 people, 15.62%
  5. Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 7 people, 10.94%
  6. Partial Seizures With Secondary Generalisation (partial seizure may spread within the brain, a process known as secondary generalization): 4 people, 6.25%
  7. Rashes (redness): 4 people, 6.25%
  8. Drug Resistance (reduction in effectiveness of a drug): 4 people, 6.25%
  9. Abnormal Behavior: 3 people, 4.69%
  10. Fever: 3 people, 4.69%

What are the existing conditions these people have? *

  1. Partial Seizures (seizures which affect only a part of the brain at onset): 7 people, 10.94%
  2. Status Epilepticus (a life-threatening condition in which the brain is in a state of persistent seizure): 6 people, 9.38%
  3. Nervousness: 4 people, 6.25%
  4. Urinary Tract Infection: 4 people, 6.25%
  5. Stress And Anxiety: 4 people, 6.25%
  6. Sedation: 4 people, 6.25%
  7. Myoclonic Epilepsy (type of epilepsy with quick little jerks of the arms, shoulder, or occasionally the legs): 4 people, 6.25%
  8. Depression: 2 people, 3.12%
  9. Lennox-Gastaut Syndrome (epilepsy characterized by frequent seizures and different seizure types): 2 people, 3.12%
  10. Growth Hormone Deficiency: 2 people, 3.12%

* Approximation only. Some reports may have incomplete information.

Do you take Valproic acid and have Tonic convulsion?

- Check whether Tonic convulsion is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valproic acid:

Tonic convulsion treatments and more:

How severe was Tonic convulsion and when was it recovered:

Expand to all the drugs that have ingredients of valproic acid:

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Valproic acid:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Tonic convulsion:

Browse all the conditions that are associated with Tonic convulsion:

Related publications that referenced our studies

How the study uses the data?

The study uses data from the FDA. It is based on valproic acid (the active ingredients of Valproic acid) and Valproic acid (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.

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