Valtrex and Decreased activity - a phase IV clinical study of FDA data

Summary:

Decreased activity is reported as a side effect among people who take Valtrex (valacyclovir hydrochloride), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Truvada, and have Hiv infection.

The phase IV clinical study analyzes which people have Decreased activity when taking Valtrex. It is created by eHealthMe based on reports of 38,014 people who have side effects when taking Valtrex from the FDA, and is updated regularly.

What is Valtrex?

Valtrex has active ingredients of valacyclovir hydrochloride. It is often used in genital herpes. eHealthMe is studying from 40,000 Valtrex users. Check the latest studies of Valtrex.

What is Decreased activity?

Decreased activity is found to be associated with 1,109 drugs and 1,330 conditions by eHealthMe. Check the latest studies of Decreased activity.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

38,014 people reported to have side effects when taking Valtrex.
Among them, 91 people (0.24%) have Decreased activity.

Among these 91 people:

How long have people been on Valtrex when they have Decreased activity? *

What is the gender of people who have Decreased activity when taking Valtrex? *

female: 53.09 %
male: 46.91 %

What is the age of people who have Decreased activity when taking Valtrex? *

What are other drugs people take besides Valtrex? *

What are other side effects people have besides Decreased activity? *

Pain: 42 people, 46.15%
Emotional Distress: 35 people, 38.46%
Stress And Anxiety: 34 people, 37.36%
Anhedonia (inability to experience pleasure from activities usually found enjoyable): 33 people, 36.26%
Acute Kidney Failure: 31 people, 34.07%
Quality Of Life Decreased: 26 people, 28.57%
Fatigue (feeling of tiredness): 22 people, 24.18%
Nausea (feeling of having an urge to vomit): 21 people, 23.08%
Joint Pain: 16 people, 17.58%
Osteoporosis (bones weak and more likely to break): 16 people, 17.58%

What are the existing conditions these people have? *

Hiv Infection: 34 people, 37.36%
High Blood Pressure: 16 people, 17.58%
Pain: 10 people, 10.99%
Asthma: 7 people, 7.69%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 7 people, 7.69%
Ovarian Cancer (cancer of ovary): 7 people, 7.69%
Infection: 6 people, 6.59%
Insomnia (sleeplessness): 6 people, 6.59%
Multiple Myeloma (cancer of the plasma cells): 6 people, 6.59%
Viral Infection: 6 people, 6.59%

* Approximation only. Some reports may have incomplete information.

Do you take Valtrex and have Decreased activity?

- Check whether Decreased activity is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Valtrex:

Valtrex (40,000 reports)

Browse all side effects of Valtrex:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Decreased activity:

Decreased activity (1,109 drugs)

Browse all the conditions that are associated with Decreased activity:

Decreased activity (1,330 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on valacyclovir hydrochloride (the active ingredients of Valtrex) and Valtrex (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.