Versed and Ear barotrauma - a phase IV clinical study of FDA data

Summary:

Ear barotrauma is reported as a side effect among people who take Versed (midazolam hydrochloride), especially for people who are female, 60+ old, also take Zantac, and have Osteoporosis.

The phase IV clinical study analyzes which people have Ear barotrauma when taking Versed. It is created by eHealthMe based on reports of 6,758 people who have side effects when taking Versed from the FDA, and is updated regularly.

What is Versed?

Versed has active ingredients of midazolam hydrochloride. It is often used in sedation during medical procedure. eHealthMe is studying from 6,869 Versed users. Check the latest studies of Versed.

What is Ear barotrauma?

Ear barotrauma (discomfort and possible damage in the ear due to pressure differences between the inside and outside of the eardrum) is found to be associated with 300 drugs and 625 conditions by eHealthMe. Check the latest studies of Ear barotrauma.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Jul, 24, 2026

6,758 people reported to have side effects when taking Versed.
Among them, 20 people (0.3%) have Ear barotrauma.

Among these 20 people:

What is the gender of people who have Ear barotrauma when taking Versed? *

female: 78.95 %
male: 21.05 %

What is the age of people who have Ear barotrauma when taking Versed? *

What are other drugs people take besides Versed? *

What are other side effects people have besides Ear barotrauma? *

Cachexia (loss of weight): 20 people, 100.00%
Vision Blurred: 20 people, 100.00%
Malnutrition (a condition that results from eating a diet in which certain nutrients are lacking): 20 people, 100.00%
High Blood Pressure: 20 people, 100.00%
Hearing Loss: 20 people, 100.00%
Swelling Face: 20 people, 100.00%
Osteonecrosis Of Jaw (death of bone of jaw): 20 people, 100.00%
Stress And Anxiety: 20 people, 100.00%
Dyspnea (difficult or laboured breathing): 20 people, 100.00%
Pain: 20 people, 100.00%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 16 people, 80.00%
Sleep Disorder: 4 people, 20.00%
Prostate Cancer Metastatic: 4 people, 20.00%
Prostate Cancer: 4 people, 20.00%
Pain: 4 people, 20.00%
Neoplasm Malignant (cancer tumour): 4 people, 20.00%
Eczema (patches of skin become rough and inflamed, with itching and bleeding blisters): 4 people, 20.00%
Chest Pain: 4 people, 20.00%
Sinus Disorder (disease of sinus): 1 person, 5.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 1 person, 5.00%

* Approximation only. Some reports may have incomplete information.

Do you take Versed and have Ear barotrauma?

- Check whether Ear barotrauma is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Versed:

Versed (6,869 reports)

Ear barotrauma treatments and more:

Ear barotrauma (1,478 reports)

Browse all side effects of Versed:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Ear barotrauma:

Ear barotrauma (300 drugs)

Browse all the conditions that are associated with Ear barotrauma:

Ear barotrauma (625 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on midazolam hydrochloride (the active ingredients of Versed) and Versed (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.