Vesicare and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Vesicare (solifenacin succinate), especially for people who are female, 60+ old, also take Zyrtec, and have Narcolepsy.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Vesicare. It is created by eHealthMe based on reports of 29,875 people who have side effects when taking Vesicare from the FDA, and is updated regularly.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,656 Vesicare users. Check the latest studies of Vesicare.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 954 drugs and 1,228 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

On Jul, 16, 2026

29,875 people reported to have side effects when taking Vesicare.
Among them, 60 people (0.2%) have Knee joint replacement.

Could Vesicare cause Knee joint replacement?

Among these 60 people:

What is the gender of people who have Knee joint replacement when taking Vesicare? *

female: 77.59 %
male: 22.41 %

What is the age of people who have Knee joint replacement when taking Vesicare? *

What are other drugs people take besides Vesicare? *

Zyrtec: 13 people, 21.67%
Calcium: 11 people, 18.33%
Synthroid: 11 people, 18.33%
Lyrica: 9 people, 15.00%
Xyrem: 9 people, 15.00%
Zoloft: 8 people, 13.33%
Oxycodone And Acetaminophen: 8 people, 13.33%
Lasix: 8 people, 13.33%
Buspirone Hcl: 7 people, 11.67%
Lipitor: 7 people, 11.67%

What are other side effects people have besides Knee joint replacement? *

Urinary Tract Infection: 13 people, 21.67%
Middle Ear Effusion (fluid in middle ear): 6 people, 10.00%
Injection Site Rash: 6 people, 10.00%
Infusion Site Erythema (reddening of the skin at infusion site): 6 people, 10.00%
Irritable Bowel Syndrome: 6 people, 10.00%
Cystitis Interstitial (unknown cause characterized by bladder pain): 6 people, 10.00%
Back Pain: 6 people, 10.00%
Tooth Disorder (tooth disease): 5 people, 8.33%
Headache (pain in head): 5 people, 8.33%
Infusion Site Pain: 4 people, 6.67%

What are the existing conditions these people have? *

Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 9 people, 15.00%
Immunodeficiency Common Variable: 7 people, 11.67%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 7 people, 11.67%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 10.00%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 6 people, 10.00%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 5 people, 8.33%
Psoriasis (immune-mediated disease that affects the skin): 4 people, 6.67%
High Blood Cholesterol: 4 people, 6.67%
High Blood Pressure: 4 people, 6.67%
Hypertonic Bladder (bladder-storage function that causes a sudden urge to urinate): 4 people, 6.67%

* Approximation only. Some reports may have incomplete information.

Do you take Vesicare and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vesicare:

Vesicare (30,656 reports)

Browse all side effects of Vesicare:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (954 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,228 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on solifenacin succinate (the active ingredients of Vesicare) and Vesicare (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.