Vesicare and Metabolic encephalopathy - a phase IV clinical study of FDA data

Summary:

Metabolic encephalopathy is reported as a side effect among people who take Vesicare (solifenacin succinate), especially for people who are female, 60+ old, also take Zanaflex, and have Multiple sclerosis.

The phase IV clinical study analyzes which people have Metabolic encephalopathy when taking Vesicare. It is created by eHealthMe based on reports of 29,875 people who have side effects when taking Vesicare from the FDA, and is updated regularly.

What is Vesicare?

Vesicare has active ingredients of solifenacin succinate. It is often used in urge incontinence. eHealthMe is studying from 30,655 Vesicare users. Check the latest studies of Vesicare.

What is Metabolic encephalopathy?

Metabolic encephalopathy (disorder or disease of the brain due to the body's disability to use energy) is found to be associated with 549 drugs and 591 conditions by eHealthMe. Check the latest studies of Metabolic encephalopathy.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

29,875 people reported to have side effects when taking Vesicare.
Among them, 14 people (0.05%) have Metabolic encephalopathy.

Could Vesicare cause Metabolic encephalopathy?

Among these 14 people:

What is the gender of people who have Metabolic encephalopathy when taking Vesicare? *

female: 84.62 %
male: 15.38 %

What is the age of people who have Metabolic encephalopathy when taking Vesicare? *

What are other drugs people take besides Vesicare? *

What are other side effects people have besides Metabolic encephalopathy? *

Multiple Sclerosis Relapse (reoccurrence of a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 6 people, 42.86%
Hypokalemia (low potassium): 6 people, 42.86%
Mental Status Changes (general changes in brain function, such as confusion, amnesia (memory loss), loss of alertness, loss of orientation): 5 people, 35.71%
Hypoglycemia (low blood sugar): 5 people, 35.71%
Hepatomegaly (abnormal enlargement of the liver): 4 people, 28.57%
Kidney Stones: 4 people, 28.57%
Iron Deficiency: 4 people, 28.57%
Hypernatraemia (an abnormally high plasma concentration of sodium ions): 4 people, 28.57%
Urinary Tract Infection Pseudomonal: 4 people, 28.57%
Metabolic Acidosis (body produces too much acid, or when the kidneys are not removing enough acid from the body): 4 people, 28.57%

What are the existing conditions these people have? *

Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 57.14%
Cough: 4 people, 28.57%
Sleep Disorder: 4 people, 28.57%
Oral Herpes (viral infection of mouth): 4 people, 28.57%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 14.29%
Stress And Anxiety: 2 people, 14.29%
Gait Disturbance: 2 people, 14.29%
High Blood Pressure: 2 people, 14.29%
Type 1 Diabetes: 2 people, 14.29%
Muscle Spasticity (tight or stiff muscles and an inability to control those muscles): 2 people, 14.29%

* Approximation only. Some reports may have incomplete information.

Do you take Vesicare and have Metabolic encephalopathy?

- Check whether Metabolic encephalopathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vesicare:

Vesicare (30,655 reports)

Browse all side effects of Vesicare:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Metabolic encephalopathy:

Metabolic encephalopathy (549 drugs)

Browse all the conditions that are associated with Metabolic encephalopathy:

Metabolic encephalopathy (591 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on solifenacin succinate (the active ingredients of Vesicare) and Vesicare (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.