Vibramycin and Malaise - a phase IV clinical study of FDA data

Summary:

Malaise is reported as a side effect among people who take Vibramycin (doxycycline), especially for people who are female, 60+ old, have been taking the drug for < 1 month also take Lisinopril, and have Multiple myeloma.

The phase IV clinical study analyzes which people have Malaise when taking Vibramycin. It is created by eHealthMe based on reports of 1,632 people who have side effects when taking Vibramycin from the FDA, and is updated regularly.

What is Vibramycin?

Vibramycin has active ingredients of doxycycline. It is often used in acne. eHealthMe is studying from 1,692 Vibramycin users. Check the latest studies of Vibramycin.

What is Malaise?

Malaise (a feeling of general discomfort or uneasiness) is found to be associated with 3,530 drugs and 5,117 conditions by eHealthMe. Check the latest studies of Malaise.

On May, 22, 2026

1,632 people reported to have side effects when taking Vibramycin.
Among them, 51 people (3.13%) have Malaise.

Among these 51 people:

How long have people been on Vibramycin when they have Malaise? *

What is the gender of people who have Malaise when taking Vibramycin? *

female: 59.18 %
male: 40.82 %

What is the age of people who have Malaise when taking Vibramycin? *

What are other drugs people take besides Vibramycin? *

What are other side effects people have besides Malaise? *

Weakness: 15 people, 29.41%
Dyspnea (difficult or laboured breathing): 14 people, 27.45%
Stress And Anxiety: 14 people, 27.45%
Fever: 13 people, 25.49%
Pain: 11 people, 21.57%
Nausea (feeling of having an urge to vomit): 11 people, 21.57%
Neuropathy Peripheral (surface nerve damage): 11 people, 21.57%
Dizziness: 11 people, 21.57%
Osteopenia (a condition where bone mineral density is lower than normal): 9 people, 17.65%
Gait Disturbance: 9 people, 17.65%

What are the existing conditions these people have? *

Multiple Myeloma (cancer of the plasma cells): 9 people, 17.65%
High Blood Pressure: 3 people, 5.88%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 3 people, 5.88%
Diabetes: 3 people, 5.88%
High Blood Cholesterol: 3 people, 5.88%
Nausea (feeling of having an urge to vomit): 2 people, 3.92%
Asthma: 2 people, 3.92%
Cardiac Failure: 2 people, 3.92%
Chronic Myeloid Leukaemia (long lasting type of cancer that starts in the blood-forming cells of the bone marrow and invades the blood): 2 people, 3.92%
Gout (uric acid crystals building up in the body): 2 people, 3.92%

* Approximation only. Some reports may have incomplete information.

Do you take Vibramycin and have Malaise?

- Check whether Malaise is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vibramycin:

Vibramycin (1,692 reports)

Malaise treatments and more:

Malaise (529,933 reports)

Browse all side effects of Vibramycin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Malaise:

Malaise (3,530 drugs)

Browse all the conditions that are associated with Malaise:

Malaise (5,117 conditions)

Related publications that referenced our studies

Dmour HH, Zayadeen AR, Shawagfeh JS, "Effect of Long Term Prophylaxis of Antimalarial Drug (Doxycycline) on Liver Span by Ultrasound", Middle East Journal of Internal Medicine, 2013 Jan .
Dmour HH, Zayadeen AR, Shawagfeh JS, "Effect of Long Term Prophylaxis of Antimalarial Drug (Doxycycline) on Liver Span by Ultrasound", Middle East Journal of Internal Medicine, 2013 Jan .

How the study uses the data?

The study uses data from the FDA. It is based on doxycycline (the active ingredients of Vibramycin) and Vibramycin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.