Vicodin and Aortic atherosclerosis - a phase IV clinical study of FDA data

Summary:

Aortic atherosclerosis is reported as a side effect among people who take Vicodin (acetaminophen; hydrocodone bitartrate), especially for people who are male, 50-59 old, also take Vioxx, and have High blood pressure.

The phase IV clinical study analyzes which people have Aortic atherosclerosis when taking Vicodin. It is created by eHealthMe based on reports of 59,416 people who have side effects when taking Vicodin from the FDA, and is updated regularly.

What is Vicodin?

Vicodin has active ingredients of acetaminophen; hydrocodone bitartrate. It is often used in pain. eHealthMe is studying from 63,357 Vicodin users. Check the latest studies of Vicodin.

What is Aortic atherosclerosis?

Aortic atherosclerosis (degenerative process of aortic arteries) is found to be associated with 102 drugs and 159 conditions by eHealthMe. Check the latest studies of Aortic atherosclerosis.

On Jul, 15, 2026

59,416 people reported to have side effects when taking Vicodin.
Among them, 19 people (0.03%) have Aortic atherosclerosis.

Could Vicodin cause Aortic atherosclerosis?

Among these 19 people:

What is the gender of people who have Aortic atherosclerosis when taking Vicodin? *

female: 26.32 %
male: 73.68 %

What is the age of people who have Aortic atherosclerosis when taking Vicodin? *

What are other drugs people take besides Vicodin? *

What are other side effects people have besides Aortic atherosclerosis? *

Coronary Heart Disease (narrowing or blockage of the coronary arteries): 11 people, 57.89%
Mitral Valve Incompetence (inefficient heart valve): 11 people, 57.89%
Emotional Distress: 9 people, 47.37%
High Blood Pressure: 8 people, 42.11%
Ventricular Hypertrophy (enlargement of ventricles (lower chambers) in the heart): 7 people, 36.84%
Ventricular Extrasystoles (premature cardiac contraction): 7 people, 36.84%
Dyspnea (difficult or laboured breathing): 7 people, 36.84%
High Blood Cholesterol: 6 people, 31.58%
Depression: 6 people, 31.58%
Hepatic Congestion (liver congestion): 5 people, 26.32%

What are the existing conditions these people have? *

High Blood Pressure: 4 people, 21.05%
Musculoskeletal Chest Pain (pain in chest muscle or nerve or bones): 3 people, 15.79%
Pain In Extremity: 1 person, 5.26%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 1 person, 5.26%
Mania (a state of abnormally elevated or irritable mood): 1 person, 5.26%
Localised Osteoarthritis (infection of joint affects only single joint): 1 person, 5.26%
Ill-Defined Disorder: 1 person, 5.26%
Hyperlipidaemia (presence of excess lipids in the blood): 1 person, 5.26%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Vicodin and have Aortic atherosclerosis?

- Check whether Aortic atherosclerosis is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vicodin:

Vicodin (63,357 reports)

Aortic atherosclerosis treatments and more:

Aortic atherosclerosis (534 reports)

How severe was Aortic atherosclerosis and when was it recovered:

Aortic atherosclerosis in Vicodin

Expand to all the drugs that have ingredients of acetaminophen; hydrocodone bitartrate:

Aortic atherosclerosis and drugs with ingredients of acetaminophen; hydrocodone bitartrate

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vicodin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Aortic atherosclerosis:

Aortic atherosclerosis (102 drugs)

Browse all the conditions that are associated with Aortic atherosclerosis:

Aortic atherosclerosis (159 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on acetaminophen; hydrocodone bitartrate (the active ingredients of Vicodin) and Vicodin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.