Vitamin b12 and Executive dysfunction - a phase IV clinical study of FDA data

Summary:

Executive dysfunction is reported as a side effect among people who take Vitamin b12 (cobalamin), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Sertraline, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Executive dysfunction when taking Vitamin b12. It is created by eHealthMe based on reports of 119,611 people who have side effects when taking Vitamin b12 from the FDA, and is updated regularly.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,680 Vitamin b12 users. Check the latest studies of Vitamin b12.

What is Executive dysfunction?

Executive dysfunction is found to be associated with 50 drugs and 130 conditions by eHealthMe. Check the latest studies of Executive dysfunction.

On Apr, 27, 2026

119,611 people reported to have side effects when taking Vitamin b12.
Among them, 11 people (0.01%) have Executive dysfunction.

Could Vitamin b12 cause Executive dysfunction?

Among these 11 people:

How long have people been on Vitamin b12 when they have Executive dysfunction? *

What is the gender of people who have Executive dysfunction when taking Vitamin b12? *

female: 81.82 %
male: 18.18 %

What is the age of people who have Executive dysfunction when taking Vitamin b12? *

What are other drugs people take besides Vitamin b12? *

What are other side effects people have besides Executive dysfunction? *

Constipation: 5 people, 45.45%
Hallucinations (sensations that appear real but are created by your mind): 5 people, 45.45%
Weakness: 4 people, 36.36%
Confusional State: 4 people, 36.36%
Cognitive Disorder (mental health disorders affects learning, memory, perception, and problem solving): 3 people, 27.27%
Dyskinesia (abnormality or impairment of voluntary movement): 3 people, 27.27%
Feeling Abnormal: 3 people, 27.27%
Dementia (madness): 3 people, 27.27%
Speech Impairment (Adult) (inability to speak (adult)): 3 people, 27.27%
Stress And Anxiety: 3 people, 27.27%

What are the existing conditions these people have? *

Parkinson's Disease: 5 people, 45.45%
Sleep Disorder: 3 people, 27.27%
Vitamin B12 Decreased: 2 people, 18.18%
Systemic Mastocytosis (a condition caused by the accumulation of mast cells in more than one part of the body): 2 people, 18.18%
Osteoporosis (bones weak and more likely to break): 2 people, 18.18%
Hallucinations (sensations that appear real but are created by your mind): 2 people, 18.18%
Bronchitis (inflammation of the mucous membrane in the bronchial tubes): 2 people, 18.18%
Affective Disorder (mental disorder): 2 people, 18.18%
Weight Loss: 1 person, 9.09%
Urinary Tract Infection: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin b12 and have Executive dysfunction?

- Check whether Executive dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin b12:

Vitamin b12 (121,680 reports)

Browse all side effects of Vitamin b12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Executive dysfunction:

Executive dysfunction (50 drugs)

Browse all the conditions that are associated with Executive dysfunction:

Executive dysfunction (130 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of Vitamin b12) and Vitamin b12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.