Vitamin b12 and Eyelid margin crusting - a phase IV clinical study of FDA data

Summary:

Eyelid margin crusting is reported as a side effect among people who take Vitamin b12 (cobalamin), especially for people who are female, 60+ old, also take Gabapentin, and have Immunodeficiency common variable.

The phase IV clinical study analyzes which people have Eyelid margin crusting when taking Vitamin b12. It is created by eHealthMe based on reports of 119,611 people who have side effects when taking Vitamin b12 from the FDA, and is updated regularly.

What is Vitamin b12?

Vitamin b12 has active ingredients of cobalamin. It is often used in vitamin b12 deficiency. eHealthMe is studying from 121,681 Vitamin b12 users. Check the latest studies of Vitamin b12.

What is Eyelid margin crusting?

Eyelid margin crusting (crusting at the lid margins, generally worse on waking) is found to be associated with 194 drugs and 279 conditions by eHealthMe. Check the latest studies of Eyelid margin crusting.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 26, 2026

119,611 people reported to have side effects when taking Vitamin b12.
Among them, 22 people (0.02%) have Eyelid margin crusting.

Could Vitamin b12 cause Eyelid margin crusting?

Among these 22 people:

What is the gender of people who have Eyelid margin crusting when taking Vitamin b12? *

female: 86.36 %
male: 13.64 %

What is the age of people who have Eyelid margin crusting when taking Vitamin b12? *

What are other drugs people take besides Vitamin b12? *

What are other side effects people have besides Eyelid margin crusting? *

Lacrimation Increased: 6 people, 27.27%
Ocular Hyperaemia (an abnormally large amount of blood in eye): 5 people, 22.73%
Productive Cough: 5 people, 22.73%
Impaired Healing: 4 people, 18.18%
Blood Glucose Decreased: 4 people, 18.18%
Gastroenteritis Viral (inflammation of stomach and intestine caused by virus infection): 4 people, 18.18%
Catheter Site Infection (infection at the site of insertion): 4 people, 18.18%
Fever: 4 people, 18.18%
Eye Pruritus (eye itching): 4 people, 18.18%
Nausea And Vomiting: 4 people, 18.18%

What are the existing conditions these people have? *

Thrombocytopenia (decrease of platelets in blood): 4 people, 18.18%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 4 people, 18.18%
Immunodeficiency: 4 people, 18.18%
Lymphocytic Leukaemia (a type of cancer in which the bone marrow makes too many lymphocytes): 4 people, 18.18%
Immunodeficiency Common Variable: 4 people, 18.18%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 2 people, 9.09%
Urinary Tract Infection: 1 person, 4.55%
Indigestion: 1 person, 4.55%
Chronic Lymphocytic Leukaemia (cancer in which the bone marrow makes too many lymphocytes (a type of white blood cell)): 1 person, 4.55%
Essential Hypertension (primary hypertension): 1 person, 4.55%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin b12 and have Eyelid margin crusting?

- Check whether Eyelid margin crusting is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin b12:

Vitamin b12 (121,681 reports)

Browse all side effects of Vitamin b12:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Eyelid margin crusting:

Eyelid margin crusting (194 drugs)

Browse all the conditions that are associated with Eyelid margin crusting:

Eyelid margin crusting (279 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cobalamin (the active ingredients of Vitamin b12) and Vitamin b12 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.