Vitamin d3 and Macule - a phase IV clinical study of FDA data

Summary:

Macule is reported as a side effect among people who take Vitamin d3 (cholecalciferol), especially for people who are female, 60+ old, also take Celebrex, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Macule when taking Vitamin d3. It is created by eHealthMe based on reports of 31,612 people who have side effects when taking Vitamin d3 from the FDA, and is updated regularly.

What is Vitamin d3?

Vitamin d3 has active ingredients of cholecalciferol. It is often used in heart health. eHealthMe is studying from 32,172 Vitamin d3 users. Check the latest studies of Vitamin d3.

What is Macule?

Macule (a discoloured spot on the skin) is found to be associated with 289 drugs and 709 conditions by eHealthMe. Check the latest studies of Macule.

On Aug, 13, 2026

31,612 people reported to have side effects when taking Vitamin d3.
Among them, 12 people (0.04%) have Macule.

Among these 12 people:

What is the gender of people who have Macule when taking Vitamin d3? *

female: 83.33 %
male: 16.67 %

What is the age of people who have Macule when taking Vitamin d3? *

What are other drugs people take besides Vitamin d3? *

What are other side effects people have besides Macule? *

Headache (pain in head): 4 people, 33.33%
Urticaria (rash of round, red welts on the skin that itch intensely): 3 people, 25.00%
Itching: 3 people, 25.00%
Depression: 3 people, 25.00%
Rashes (redness): 3 people, 25.00%
Fatigue (feeling of tiredness): 3 people, 25.00%
Weight Decreased: 2 people, 16.67%
Hypotension (abnormally low blood pressure): 2 people, 16.67%
Peripheral Swelling: 2 people, 16.67%
Oxygen Saturation Decreased: 2 people, 16.67%

What are the existing conditions these people have? *

Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 4 people, 33.33%
Diabetes: 3 people, 25.00%
High Blood Cholesterol: 2 people, 16.67%
Osteoporosis Post-Menopausal (weak bone with possibility to break after stopped menstrual cycles): 2 people, 16.67%
Thyroid Diseases: 1 person, 8.33%
Multiple Myeloma (cancer of the plasma cells): 1 person, 8.33%
Breast Cancer: 1 person, 8.33%
Hair Loss: 1 person, 8.33%
Infection: 1 person, 8.33%
Metastatic Malignant Melanoma (spreadable cancer tumour of melanine): 1 person, 8.33%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin d3 and have Macule?

- Check whether Macule is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin d3:

Vitamin d3 (32,172 reports)

Macule treatments and more:

Macule (3,263 reports)

Browse all side effects of Vitamin d3:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Macule:

Macule (289 drugs)

Browse all the conditions that are associated with Macule:

Macule (709 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on cholecalciferol (the active ingredients of Vitamin d3) and Vitamin d3 (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.