Vitamin e and Difficulty falling asleep - a phase IV clinical study of FDA data

Summary:

Difficulty falling asleep is reported as a side effect among people who take Vitamin e (tocopherols and tocotrienols), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Vitamin C, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Difficulty falling asleep when taking Vitamin e. It is created by eHealthMe based on reports of 41,364 people who have side effects when taking Vitamin e from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,278 Vitamin e users. Check the latest studies of Vitamin e.

What is Difficulty falling asleep?

Difficulty falling asleep is found to be associated with 4,581 drugs and 5,396 conditions by eHealthMe. Check the latest studies of Difficulty falling asleep.

On May, 07, 2026

41,364 people reported to have side effects when taking Vitamin e.
Among them, 1,267 people (3.06%) have Difficulty falling asleep.

Could Vitamin e cause Difficulty falling asleep?

Among these 1,267 people:

How long have people been on Vitamin e when they have Difficulty falling asleep? *

Click here to view more results

What is the gender of people who have Difficulty falling asleep when taking Vitamin e? *

Click here to view

What is the age of people who have Difficulty falling asleep when taking Vitamin e? *

Click here to view more results

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin e and have Difficulty falling asleep?

- Check whether Difficulty falling asleep is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin e:

Vitamin e (42,278 reports)

Difficulty falling asleep treatments and more:

Difficulty falling asleep (438,064 reports)

How severe was Difficulty falling asleep and when was it recovered:

Difficulty falling asleep in Vitamin e

Expand to all the drugs that have ingredients of tocopherols and tocotrienols:

Difficulty falling asleep and drugs with ingredients of tocopherols and tocotrienols (1,277 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vitamin e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Difficulty falling asleep:

Difficulty falling asleep (4,581 drugs)

Browse all the conditions that are associated with Difficulty falling asleep:

Difficulty falling asleep (5,396 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tocopherols and tocotrienols (the active ingredients of Vitamin e) and Vitamin e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.