Vitamin e and Headache - a phase IV clinical study of FDA data

Summary:

Headache is reported as a side effect among people who take Vitamin e (tocopherols and tocotrienols), especially for people who are female, 60+ old, have been taking the drug for 1 - 6 months also take Vitamin C, and have Rheumatoid arthritis.

The phase IV clinical study analyzes which people have Headache when taking Vitamin e. It is created by eHealthMe based on reports of 41,364 people who have side effects when taking Vitamin e from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,276 Vitamin e users. Check the latest studies of Vitamin e.

What is Headache?

Headache (pain in head) is found to be associated with 3,744 drugs and 5,746 conditions by eHealthMe. Check the latest studies of Headache.

On Jan, 26, 2026

41,364 people reported to have side effects when taking Vitamin e.
Among them, 2,789 people (6.74%) have Headache.

Among these 2,789 people:

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin e and have Headache?

- Check whether Headache is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin e:

Vitamin e (42,276 reports)

Headache treatments and more:

Headache (756,631 reports)

How severe was Headache and when was it recovered:

Headache in Vitamin e

Expand to all the drugs that have ingredients of tocopherols and tocotrienols:

Headache and drugs with ingredients of tocopherols and tocotrienols (2,803 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Common Vitamin e side effects:

Browse all side effects of Vitamin e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Headache:

Browse all the drugs that are associated with Headache:

Headache (3,744 drugs)

Common conditions associated with Headache:

Rheumatoid arthritis aggravated: 48,568 reports
Ra: 48,495 reports
Ms: 46,561 reports
Sporadic primary pulmonary hypertension: 26,210 reports
Hypertension: 25,824 reports
Blood pressure - high: 25,672 reports
Plaque psoriasis: 22,394 reports
Depression: 20,062 reports
Antidepressant therapy: 19,997 reports
Pain: 19,938 reports

Browse all the conditions that are associated with Headache:

Headache (5,746 conditions)

Drugs similar to Vitamin e and Headache :

How the study uses the data?

The study uses data from the FDA. It is based on tocopherols and tocotrienols (the active ingredients of Vitamin e) and Vitamin e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.