Vitamin e and Joint crepitation - a phase IV clinical study of FDA data

Summary:

Joint crepitation is reported as a side effect among people who take Vitamin e (tocopherols and tocotrienols), especially for people who are female, 60+ old, have been taking the drug for 10+ years also take Vitamin D, and have Osteoporosis.

The phase IV clinical study analyzes which people have Joint crepitation when taking Vitamin e. It is created by eHealthMe based on reports of 41,364 people who have side effects when taking Vitamin e from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,279 Vitamin e users. Check the latest studies of Vitamin e.

What is Joint crepitation?

Joint crepitation is found to be associated with 288 drugs and 740 conditions by eHealthMe. Check the latest studies of Joint crepitation.

On Jul, 17, 2026

41,364 people reported to have side effects when taking Vitamin e.
Among them, 26 people (0.06%) have Joint crepitation.

Could Vitamin e cause Joint crepitation?

Among these 26 people:

How long have people been on Vitamin e when they have Joint crepitation? *

What is the gender of people who have Joint crepitation when taking Vitamin e? *

female: 80 %
male: 20 %

What is the age of people who have Joint crepitation when taking Vitamin e? *

What are other drugs people take besides Vitamin e? *

What are other side effects people have besides Joint crepitation? *

Joint Pain: 18 people, 69.23%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 10 people, 38.46%
Arthritis (form of joint disorder that involves inflammation of one or more joints): 9 people, 34.62%
Arthropathy: 9 people, 34.62%
Joint Effusion (presence of extra fluid in joint covering): 8 people, 30.77%
Pain: 8 people, 30.77%
Pain In Extremity: 8 people, 30.77%
Arrhythmias (irregular heartbeat): 7 people, 26.92%
Oedema Peripheral (superficial swelling): 7 people, 26.92%
Hypoaesthesia (reduced sense of touch or sensation): 7 people, 26.92%

What are the existing conditions these people have? *

Osteoporosis (bones weak and more likely to break): 7 people, 26.92%
Breast Cancer: 4 people, 15.38%
High Blood Pressure: 4 people, 15.38%
Metastases To Bone (cancer spreads to bone): 4 people, 15.38%
Multiple Myeloma (cancer of the plasma cells): 4 people, 15.38%
High Blood Cholesterol: 3 people, 11.54%
Osteopenia (a condition where bone mineral density is lower than normal): 2 people, 7.69%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 2 people, 7.69%
Seasonal Allergy (allergic condition due to certain season): 2 people, 7.69%
Back Pain: 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin e and have Joint crepitation?

- Check whether Joint crepitation is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin e:

Vitamin e (42,279 reports)

Browse all side effects of Vitamin e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Joint crepitation:

Joint crepitation (288 drugs)

Browse all the conditions that are associated with Joint crepitation:

Joint crepitation (740 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tocopherols and tocotrienols (the active ingredients of Vitamin e) and Vitamin e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.