Vitamin e and Sciatic nerve dysfunction - a phase IV clinical study of FDA data

Summary:

Sciatic nerve dysfunction is reported as a side effect among people who take Vitamin e (tocopherols and tocotrienols), especially for people who are female, 60+ old, have been taking the drug for 1 - 2 years also take Vitamin C, and have Pain.

The phase IV clinical study analyzes which people have Sciatic nerve dysfunction when taking Vitamin e. It is created by eHealthMe based on reports of 41,364 people who have side effects when taking Vitamin e from the FDA, and is updated regularly.

What is Vitamin e?

Vitamin e has active ingredients of tocopherols and tocotrienols. It is often used in vitamin supplementation. eHealthMe is studying from 42,274 Vitamin e users. Check the latest studies of Vitamin e.

What is Sciatic nerve dysfunction?

Sciatic nerve dysfunction (a condition in which the sciatic nerve conducts impulses abnormally) is found to be associated with 1,942 drugs and 1,446 conditions by eHealthMe. Check the latest studies of Sciatic nerve dysfunction.

On Sep, 12, 2025

41,364 people reported to have side effects when taking Vitamin e.
Among them, 131 people (0.32%) have Sciatic nerve dysfunction.

Could Vitamin e cause Sciatic nerve dysfunction?

Among these 131 people:

How long have people been on Vitamin e when they have Sciatic nerve dysfunction? *

What is the gender of people who have Sciatic nerve dysfunction when taking Vitamin e? *

female: 80.33 %
male: 19.67 %

What is the age of people who have Sciatic nerve dysfunction when taking Vitamin e? *

What are other drugs people take besides Vitamin e? *

What are other side effects people have besides Sciatic nerve dysfunction? *

Fall: 43 people, 32.82%
Joint Pain: 43 people, 32.82%
Back Pain: 39 people, 29.77%
Nausea (feeling of having an urge to vomit): 34 people, 25.95%
Weakness: 32 people, 24.43%
Gait Disturbance: 31 people, 23.66%
High Blood Pressure: 30 people, 22.90%
Hypoaesthesia (reduced sense of touch or sensation): 30 people, 22.90%
Depression: 29 people, 22.14%
Osteoarthritis (a joint disease caused by cartilage loss in a joint): 24 people, 18.32%

What are the existing conditions these people have? *

Pain: 23 people, 17.56%
Osteoporosis (bones weak and more likely to break): 16 people, 12.21%
Rheumatoid Arthritis (a chronic progressive disease causing inflammation in the joints): 16 people, 12.21%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 11 people, 8.40%
Psoriasis (immune-mediated disease that affects the skin): 11 people, 8.40%
Psoriatic Arthropathy (inflammation of the skin and joints with kin condition which typically causes patches (plaques) of red, scaly skin to develop): 10 people, 7.63%
Depression: 9 people, 6.87%
Multiple Sclerosis (a nervous system disease that affects your brain and spinal cord. it damages the myelin sheath): 8 people, 6.11%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 8 people, 6.11%
High Blood Cholesterol: 7 people, 5.34%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamin e and have Sciatic nerve dysfunction?

- Check whether Sciatic nerve dysfunction is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamin e:

Vitamin e (42,274 reports)

Browse all side effects of Vitamin e:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Common drugs associated with Sciatic nerve dysfunction:

Browse all the drugs that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,942 drugs)

Common conditions associated with Sciatic nerve dysfunction:

Ra: 3,984 reports
Osteoporosis: 1,578 reports
Psoriatic arthropathy aggravated: 1,283 reports
Pain: 1,076 reports
Pain relief: 1,069 reports
Multiple sclerosis: 1,038 reports
Hypertension: 930 reports
Blood pressure - high: 922 reports
Blood triglycerides abnormal: 804 reports
Psoriasis: 785 reports

Browse all the conditions that are associated with Sciatic nerve dysfunction:

Sciatic nerve dysfunction (1,446 conditions)

Drugs similar to Vitamin e and Sciatic nerve dysfunction :

How the study uses the data?

The study uses data from the FDA. It is based on tocopherols and tocotrienols (the active ingredients of Vitamin e) and Vitamin e (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.