Vitamins and Freezing phenomenon - a phase IV clinical study of FDA data

Summary:

Freezing phenomenon is reported as a side effect among people who take Vitamins (ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e), especially for people who are female, 60+ old, also take Rytary, and have Parkinson's disease.

The phase IV clinical study analyzes which people have Freezing phenomenon when taking Vitamins. It is created by eHealthMe based on reports of 121,858 people who have side effects when taking Vitamins from the FDA, and is updated regularly.

What is Vitamins?

Vitamins has active ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e. It is often used in vitamin supplementation. eHealthMe is studying from 122,457 Vitamins users. Check the latest studies of Vitamins.

What is Freezing phenomenon?

Freezing phenomenon is found to be associated with 208 drugs and 231 conditions by eHealthMe. Check the latest studies of Freezing phenomenon.

On Jul, 31, 2026

121,858 people reported to have side effects when taking Vitamins.
Among them, 21 people (0.02%) have Freezing phenomenon.

Could Vitamins cause Freezing phenomenon?

Among these 21 people:

What is the gender of people who have Freezing phenomenon when taking Vitamins? *

female: 52.38 %
male: 47.62 %

What is the age of people who have Freezing phenomenon when taking Vitamins? *

What are other drugs people take besides Vitamins? *

What are other side effects people have besides Freezing phenomenon? *

Dyskinesia (abnormality or impairment of voluntary movement): 7 people, 33.33%
Gait Disturbance: 5 people, 23.81%
Drowsiness: 4 people, 19.05%
Confusional State: 4 people, 19.05%
Fall: 4 people, 19.05%
Weight Decreased: 4 people, 19.05%
Hallucinations (sensations that appear real but are created by your mind): 4 people, 19.05%
Tremor (trembling or shaking movements in one or more parts of your body): 4 people, 19.05%
Insomnia (sleeplessness): 3 people, 14.29%
Hypotension (abnormally low blood pressure): 3 people, 14.29%

What are the existing conditions these people have? *

Parkinson's Disease: 15 people, 71.43%
Dyskinesia (abnormality or impairment of voluntary movement): 4 people, 19.05%
Gastroesophageal Reflux Disease (a condition in which stomach contents leak backward from the stomach into the oesophagus): 2 people, 9.52%
Seborrhoeic Dermatitis (a common, inflammatory skin condition that causes flaky, white to yellowish scales to form on oily areas such as the scalp): 2 people, 9.52%
Pruritus Generalised (generalized itching): 2 people, 9.52%
Pain: 2 people, 9.52%
Itching: 2 people, 9.52%
Sleep Disorder: 2 people, 9.52%
Stress And Anxiety: 1 person, 4.76%
Appetite Disorder (abnormal eating habits): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Vitamins and have Freezing phenomenon?

- Check whether Freezing phenomenon is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vitamins:

Vitamins (122,457 reports)

Freezing phenomenon treatments and more:

Freezing phenomenon (4,725 reports)

How severe was Freezing phenomenon and when was it recovered:

Freezing phenomenon in Vitamins

Expand to all the drugs that have ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e:

Freezing phenomenon and drugs with ingredients of ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (66 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vitamins:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Freezing phenomenon:

Freezing phenomenon (208 drugs)

Browse all the conditions that are associated with Freezing phenomenon:

Freezing phenomenon (231 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ascorbic acid; biotin; cyanocobalamin; dexpanthenol; ergocalciferol; folic acid; niacinamide; pyridoxine hydrochloride; riboflavin phosphate sodium; thiamine hydrochloride; vitamin a; vitamin e (the active ingredients of Vitamins) and Vitamins (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.