Vortioxetine and Death - a phase IV clinical study of FDA data

Summary:

Death is reported as a side effect among people who take Vortioxetine (vortioxetine), especially for people who are female, 60+ old, have been taking the drug for 2 - 5 years also take Furosemide, and have Depression.

The study is created by eHealthMe based on reports of 2,398 people who have side effects when taking Vortioxetine from the FDA, and is updated regularly.

What is Vortioxetine?

Vortioxetine has active ingredients of vortioxetine. eHealthMe is studying from 2,440 Vortioxetine users. Check the latest studies of Vortioxetine.

On Jul, 16, 2026

2,398 people reported to have side effects when taking Vortioxetine.
Among them, 74 people (3.09%) died.

Among these 74 people:

How long have people been on Vortioxetine when they died? *

What is the gender of people who died when taking Vortioxetine? *

female: 56.16 %
male: 43.84 %

What is the age of people who died when taking Vortioxetine? *

What are other drugs people take besides Vortioxetine? *

Klonopin: 3 people, 4.05%
Furosemide: 3 people, 4.05%
Lanoxin: 2 people, 2.70%
Vimovo: 2 people, 2.70%
Adderall: 2 people, 2.70%
Aripiprazole: 2 people, 2.70%
Fluoxetine Hydrochloride: 2 people, 2.70%
Potassium Chloride: 2 people, 2.70%
Sertraline: 2 people, 2.70%
Clozaril: 2 people, 2.70%

What are other side effects people have before they died? *

Seizures (abnormal excessive or synchronous neuronal activity in the brain): 2 people, 2.70%
Itching: 2 people, 2.70%
Weakness: 1 person, 1.35%
Forced Expiratory Volume Increased (increased lung expired air volume): 1 person, 1.35%
Atherosclerosis (disorder of the arteries): 1 person, 1.35%
Brain Neoplasm (tumour of brain): 1 person, 1.35%
Brain Oedema (excess accumulation of fluid in the intracellular or extracellular spaces of the brain): 1 person, 1.35%
Chronic Obstructive Pulmonary Disease (a progressive disease that makes it hard to breathe): 1 person, 1.35%
Depression: 1 person, 1.35%
Drug Ineffective: 1 person, 1.35%

What are the existing conditions these people have? *

Depression: 15 people, 20.27%
Major Depression (a mood state that goes well beyond temporarily feeling sad or blue. it is a serious medical illness that affects one's thoughts, feelings): 4 people, 5.41%
High Blood Pressure: 3 people, 4.05%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 4.05%
Pain: 3 people, 4.05%
Arrhythmias (irregular heartbeat): 2 people, 2.70%
Oedema (fluid collection in tissue): 2 people, 2.70%
Cardiac Failure: 2 people, 2.70%
Inflammation: 2 people, 2.70%
Hypothyroidism (abnormally low activity of the thyroid gland, resulting in retardation of growth and mental development): 2 people, 2.70%

* Approximation only. Some reports may have incomplete information.

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vortioxetine:

Vortioxetine (2,440 reports)

Expand to all the drugs that have ingredients of vortioxetine:

Death and drugs with ingredients of vortioxetine (74 reports)

Sub-studies by gender and age:

Female: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Male: 0-1 2-9 10-19 20-29 30-39 40-49 50-59 60+

Browse all side effects of Vortioxetine:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Death:

Death (3,125 drugs)

Browse all the conditions that are associated with Death:

Death (3,686 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on vortioxetine (the active ingredients of Vortioxetine) and Vortioxetine (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.