Vyndamax and Knee joint replacement - a phase IV clinical study of FDA data

Summary:

Knee joint replacement is reported as a side effect among people who take Vyndamax (tafamidis), especially for people who are male, 60+ old, also take Eliquis, and have Amyloidosis.

The phase IV clinical study analyzes which people have Knee joint replacement when taking Vyndamax. It is created by eHealthMe based on reports of 7,874 people who have side effects when taking Vyndamax from the FDA, and is updated regularly.

What is Vyndamax?

Vyndamax has active ingredients of tafamidis. eHealthMe is studying from 7,877 Vyndamax users. Check the latest studies of Vyndamax.

What is Knee joint replacement?

Knee joint replacement is found to be associated with 946 drugs and 1,232 conditions by eHealthMe. Check the latest studies of Knee joint replacement.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 01, 2026

7,874 people reported to have side effects when taking Vyndamax.
Among them, 26 people (0.33%) have Knee joint replacement.

Could Vyndamax cause Knee joint replacement?

Among these 26 people:

What is the gender of people who have Knee joint replacement when taking Vyndamax? *

female: 20 %
male: 80 %

What is the age of people who have Knee joint replacement when taking Vyndamax? *

What are other drugs people take besides Vyndamax? *

Losartan: 4 people, 15.38%
Eliquis: 4 people, 15.38%
Xarelto: 3 people, 11.54%
Pantoprazole: 3 people, 11.54%
Ezetimibe: 3 people, 11.54%
Amlodipine: 3 people, 11.54%
Xtandi: 1 person, 3.85%
Vyndaqel: 1 person, 3.85%
Torsemide: 1 person, 3.85%
Methylphenidate Hydrochloride: 1 person, 3.85%

What are other side effects people have besides Knee joint replacement? *

Fall: 4 people, 15.38%
Dyspnea (difficult or laboured breathing): 4 people, 15.38%
Malaise (a feeling of general discomfort or uneasiness): 4 people, 15.38%
Stroke (sudden death of a portion of the brain cells due to a lack of oxygen): 3 people, 11.54%
Fatigue (feeling of tiredness): 3 people, 11.54%
Lumbar Spinal Stenosis (a medical condition in which the spinal canal narrows and compresses the spinal cord and nerves at the level of the lumbar bone): 2 people, 7.69%
Oesophageal Ulcer (ulcer of oesophagus): 2 people, 7.69%
Oropharyngeal Candidiasis (fungal infection of oropharynx): 2 people, 7.69%
Heart Rate Decreased: 2 people, 7.69%
Cataract (clouding of the lens inside the eye): 2 people, 7.69%

What are the existing conditions these people have? *

Amyloidosis (a tumour within which amyloid is produced): 7 people, 26.92%
Cardiac Amyloidosis (protein deposition in heart): 4 people, 15.38%
Heart Rate Increased: 3 people, 11.54%
Heart Rate Irregular: 2 people, 7.69%
Cardiac Disorder: 2 people, 7.69%
Atrial Fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles): 2 people, 7.69%
Thyroid Diseases: 1 person, 3.85%
Prostate Cancer: 1 person, 3.85%
High Blood Cholesterol: 1 person, 3.85%
Hereditary Neuropathic Amyloidosis (hereditary- diseases resulting from abnormal deposition of certain proteins (amyloid) in various bodily areas by problems with signals from the nerves): 1 person, 3.85%

* Approximation only. Some reports may have incomplete information.

Do you take Vyndamax and have Knee joint replacement?

- Check whether Knee joint replacement is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vyndamax:

Vyndamax (7,877 reports)

Browse all side effects of Vyndamax:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Knee joint replacement:

Knee joint replacement (946 drugs)

Browse all the conditions that are associated with Knee joint replacement:

Knee joint replacement (1,232 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on tafamidis (the active ingredients of Vyndamax) and Vyndamax (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.