Vytorin and Polyneuropathy - a phase IV clinical study of FDA data

Summary:

Polyneuropathy is reported as a side effect among people who take Vytorin (ezetimibe; simvastatin), especially for people who are female, 40-49 old, also take Lyrica, and have Neuropathy peripheral.

The phase IV clinical study analyzes which people have Polyneuropathy when taking Vytorin. It is created by eHealthMe based on reports of 19,379 people who have side effects when taking Vytorin from the FDA, and is updated regularly.

What is Vytorin?

Vytorin has active ingredients of ezetimibe; simvastatin. It is often used in high blood cholesterol. eHealthMe is studying from 20,084 Vytorin users. Check the latest studies of Vytorin.

What is Polyneuropathy?

Polyneuropathy (neurological disorder that occurs when many peripheral nerves throughout the body malfunction simultaneously) is found to be associated with 910 drugs and 944 conditions by eHealthMe. Check the latest studies of Polyneuropathy.

On Jul, 26, 2026

19,379 people reported to have side effects when taking Vytorin.
Among them, 19 people (0.1%) have Polyneuropathy.

Among these 19 people:

What is the gender of people who have Polyneuropathy when taking Vytorin? *

female: 84.21 %
male: 15.79 %

What is the age of people who have Polyneuropathy when taking Vytorin? *

What are other drugs people take besides Vytorin? *

What are other side effects people have besides Polyneuropathy? *

Pain: 8 people, 42.11%
Gait Disturbance: 7 people, 36.84%
Fatigue (feeling of tiredness): 7 people, 36.84%
Intervertebral Disc Protrusion (spinal disc protrusion): 6 people, 31.58%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 6 people, 31.58%
Pain In Extremity: 6 people, 31.58%
Weakness: 6 people, 31.58%
Glycosylated Haemoglobin Increased: 5 people, 26.32%
Weight Decreased: 5 people, 26.32%
Hypoaesthesia (reduced sense of touch or sensation): 5 people, 26.32%

What are the existing conditions these people have? *

Neuropathy Peripheral (surface nerve damage): 4 people, 21.05%
Neoplasm Malignant (cancer tumour): 3 people, 15.79%
Depression: 2 people, 10.53%
Hyperlipidaemia (presence of excess lipids in the blood): 2 people, 10.53%
Type 2 Diabetes: 1 person, 5.26%
Mood Swings (an extreme or rapid change in mood): 1 person, 5.26%
Diabetic Neuropathy (neuropathic disorders that are associated with diabetes mellitus): 1 person, 5.26%
Hypercalcaemia (elevated calcium (ca+) level in the blood): 1 person, 5.26%
Irritable Bowel Syndrome: 1 person, 5.26%
Mixed Hyperlipidaemia (elevated concentrations of any or all of the lipids in the plasma): 1 person, 5.26%

* Approximation only. Some reports may have incomplete information.

Do you take Vytorin and have Polyneuropathy?

- Check whether Polyneuropathy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Vytorin:

Vytorin (20,084 reports)

Polyneuropathy treatments and more:

Polyneuropathy (17,901 reports)

Browse all side effects of Vytorin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Polyneuropathy:

Polyneuropathy (910 drugs)

Browse all the conditions that are associated with Polyneuropathy:

Polyneuropathy (944 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on ezetimibe; simvastatin (the active ingredients of Vytorin) and Vytorin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.