Wegovy and Discomfort - a phase IV clinical study of FDA data

Summary:

Discomfort is reported as a side effect among people who take Wegovy (semaglutide), especially for people who are female, 50-59 old, have been taking the drug for < 1 month also take Metformin, and have Weight decreased.

The phase IV clinical study analyzes which people have Discomfort when taking Wegovy. It is created by eHealthMe based on reports of 4,836 people who have side effects when taking Wegovy from the FDA, and is updated regularly.

What is Wegovy?

Wegovy has active ingredients of semaglutide. It is often used in weight loss. eHealthMe is studying from 4,887 Wegovy users. Check the latest studies of Wegovy.

What is Discomfort?

Discomfort is found to be associated with 1,783 drugs and 1,566 conditions by eHealthMe. Check the latest studies of Discomfort.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Sep, 03, 2026

4,836 people reported to have side effects when taking Wegovy.
Among them, 16 people (0.33%) have Discomfort.

Among these 16 people:

How long have people been on Wegovy when they have Discomfort? *

What is the gender of people who have Discomfort when taking Wegovy? *

female: 71.43 %
male: 28.57 %

What is the age of people who have Discomfort when taking Wegovy? *

What are other drugs people take besides Wegovy? *

What are other side effects people have besides Discomfort? *

Nausea (feeling of having an urge to vomit): 5 people, 31.25%
Diarrhea: 5 people, 31.25%
Constipation: 4 people, 25.00%
Abdominal Distension: 3 people, 18.75%
Belching (release of gas from the digestive tract): 3 people, 18.75%
Fatigue (feeling of tiredness): 2 people, 12.50%
Dizziness: 2 people, 12.50%
Indigestion: 2 people, 12.50%
Muscle Tightness: 2 people, 12.50%
Nausea And Vomiting: 2 people, 12.50%

What are the existing conditions these people have? *

Weight Decreased: 3 people, 18.75%
Narcolepsy (brain's inability to regulate sleep-wake cycles normally): 1 person, 6.25%
Drowsiness: 1 person, 6.25%
Dermatitis Atopic (inflammatory, chronically relapsing, non-contagious and pruritic skin disorder): 1 person, 6.25%
Cataplexy (loss of muscle tone accompanied by full conscious awareness): 1 person, 6.25%

* Approximation only. Some reports may have incomplete information.

Do you take Wegovy and have Discomfort?

- Check whether Discomfort is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wegovy:

Wegovy (4,887 reports)

Discomfort treatments and more:

Discomfort (65,127 reports)

Browse all side effects of Wegovy:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Discomfort:

Discomfort (1,783 drugs)

Browse all the conditions that are associated with Discomfort:

Discomfort (1,566 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on semaglutide (the active ingredients of Wegovy) and Wegovy (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.