Wellbutrin sr and Cerebral atrophy - a phase IV clinical study of FDA data

Summary:

Cerebral atrophy is reported as a side effect among people who take Wellbutrin sr (bupropion hydrochloride), especially for people who are female, 50-59 old, have been taking the drug for 1 - 2 years also take Lexapro, and have Crohn's disease.

The phase IV clinical study analyzes which people have Cerebral atrophy when taking Wellbutrin sr. It is created by eHealthMe based on reports of 9,388 people who have side effects when taking Wellbutrin sr from the FDA, and is updated regularly.

What is Wellbutrin sr?

Wellbutrin sr has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 13,112 Wellbutrin sr users. Check the latest studies of Wellbutrin sr.

What is Cerebral atrophy?

Cerebral atrophy (decrement in size of brain) is found to be associated with 807 drugs and 856 conditions by eHealthMe. Check the latest studies of Cerebral atrophy.

On Jul, 20, 2026

9,388 people reported to have side effects when taking Wellbutrin sr.
Among them, 11 people (0.12%) have Cerebral atrophy.

Could Wellbutrin sr cause Cerebral atrophy?

Among these 11 people:

How long have people been on Wellbutrin sr when they have Cerebral atrophy? *

What is the gender of people who have Cerebral atrophy when taking Wellbutrin sr? *

female: 72.73 %
male: 27.27 %

What is the age of people who have Cerebral atrophy when taking Wellbutrin sr? *

What are other drugs people take besides Wellbutrin sr? *

What are other side effects people have besides Cerebral atrophy? *

Neuropathy Peripheral (surface nerve damage): 5 people, 45.45%
Pharyngitis Streptococcal (inflammation of the pharynx caused by infection from. streptococcus): 5 people, 45.45%
Headache (pain in head): 5 people, 45.45%
Infection: 5 people, 45.45%
Eczema Infected (eczema due to bacterial infection or with bacterial infection): 5 people, 45.45%
Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect): 5 people, 45.45%
Suicidal Ideation: 5 people, 45.45%
Drug Eruption (adverse drug reaction of the skin): 5 people, 45.45%
Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 45.45%
Leukoencephalopathy (disease of the white matter in the brain): 5 people, 45.45%

What are the existing conditions these people have? *

Crohn's Disease (a condition that causes inflammation of the gastrointestinal tract): 5 people, 45.45%
Schizophrenia (a mental disorder characterized by a breakdown of thought processes): 3 people, 27.27%
Agitation (state of anxiety or nervous excitement): 3 people, 27.27%
Birth Control: 2 people, 18.18%
Pain: 1 person, 9.09%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin sr and have Cerebral atrophy?

- Check whether Cerebral atrophy is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin sr:

Wellbutrin sr (13,112 reports)

Browse all side effects of Wellbutrin sr:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Cerebral atrophy:

Cerebral atrophy (807 drugs)

Browse all the conditions that are associated with Cerebral atrophy:

Cerebral atrophy (856 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin sr) and Wellbutrin sr (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.