Wellbutrin and Application site urticaria - a phase IV clinical study of FDA data

Summary:

Application site urticaria is reported as a side effect among people who take Wellbutrin (bupropion hydrochloride), especially for people who are female, 50-59 old, also take Zecuity, and have Migraine.

The phase IV clinical study analyzes which people have Application site urticaria when taking Wellbutrin. It is created by eHealthMe based on reports of 101,581 people who have side effects when taking Wellbutrin from the FDA, and is updated regularly.

What is Wellbutrin?

Wellbutrin has active ingredients of bupropion hydrochloride. It is often used in depression. eHealthMe is studying from 117,110 Wellbutrin users. Check the latest studies of Wellbutrin.

What is Application site urticaria?

Application site urticaria is found to be associated with 97 drugs and 320 conditions by eHealthMe. Check the latest studies of Application site urticaria.

eHealthMe: drug outcomes in the real world

eHealthMe runs one of the largest post-marketing drug safety studies in the world. We study millions of patients and 5,000 more each day. Our data-driven phase IV clinical trials have been referenced on 800+ peer-reviewed medical publications including The Lancet, Mayo Clinic Proceedings, and Nature. Tools to study our phase IV findings are available to the public, anonymous and free >>>.

On Aug, 20, 2026

101,581 people reported to have side effects when taking Wellbutrin.
Among them, 21 people (0.02%) have Application site urticaria.

Could Wellbutrin cause Application site urticaria?

Among these 21 people:

What is the gender of people who have Application site urticaria when taking Wellbutrin? *

female: 80 %
male: 20 %

What is the age of people who have Application site urticaria when taking Wellbutrin? *

What are other drugs people take besides Wellbutrin? *

What are other side effects people have besides Application site urticaria? *

Application Site Pruritus (application site severe itching of the skin): 16 people, 76.19%
Application Site Erythema (redness of the skin at application site): 15 people, 71.43%
Application Site Pain: 10 people, 47.62%
Application Site Irritation: 7 people, 33.33%
Application Site Burn: 7 people, 33.33%
Application Site Discoloration: 7 people, 33.33%
Application Site Discomfort: 7 people, 33.33%
Drug Ineffective: 5 people, 23.81%
Application Site Warmth: 4 people, 19.05%
Application Site Papules (solid elevation of skin with no visible fluid at application site): 3 people, 14.29%

What are the existing conditions these people have? *

Migraine (headache): 5 people, 23.81%
Quit Smoking: 3 people, 14.29%
High Blood Cholesterol: 2 people, 9.52%
Headache (pain in head): 2 people, 9.52%
Pain: 2 people, 9.52%
Nervousness: 2 people, 9.52%
Cardiac Disorder: 2 people, 9.52%
High Blood Pressure: 2 people, 9.52%
Chest Pain: 1 person, 4.76%
Complex Regional Pain Syndrome (long lasting pain condition most often affecting one of the limbs (arms, legs, hands, or feet)): 1 person, 4.76%

* Approximation only. Some reports may have incomplete information.

Do you take Wellbutrin and have Application site urticaria?

- Check whether Application site urticaria is associated with a drug or a condition
- Predict drug outcomes for up to one year with AI
- Get an AI agent to monitor your drugs continuously

Related studies:

Effectiveness of, long term effects of, and alternative drugs to Wellbutrin:

Wellbutrin (117,110 reports)

Browse all side effects of Wellbutrin:

a b c d e f g h i j k l m n o p q r s t u v w x y z

Browse all the drugs that are associated with Application site urticaria:

Application site urticaria (97 drugs)

Browse all the conditions that are associated with Application site urticaria:

Application site urticaria (320 conditions)

How the study uses the data?

The study uses data from the FDA. It is based on bupropion hydrochloride (the active ingredients of Wellbutrin) and Wellbutrin (the brand name). Other drugs that have the same active ingredients (e.g. generic drugs) are not considered. Dosage of drugs is not considered in the study.

How to use the study?

DO NOT STOP MEDICATIONS without first consulting your doctor. If there are any serious or long term adverse effects discovered in the study, discuss the study with your doctor to ensure that proper medication management will be in place if applicable.

Who is eHealthMe?

With medical big data and proven AI/ML algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. We study millions of patients and 5,000 more each day. Results of our real-world drug study have been referenced on 800+ peer-reviewed medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. Our analysis results are available to researchers, health care professionals, patients (testimonials), and software developers (open API).

WARNING, DISCLAIMER, USE FOR PUBLICATION

WARNING: Please DO NOT STOP MEDICATIONS without first consulting a physician since doing so could be hazardous to your health.

DISCLAIMER: All material available on eHealthMe.com is for informational purposes only, and is not a substitute for medical advice, diagnosis, or treatment provided by a qualified healthcare provider. All information is observation-only. Our phase IV clinical studies alone cannot establish cause-effect relationship. Different individuals may respond to medication in different ways. Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. The use of the eHealthMe site and its content is at your own risk.

If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date.